Protein-based underwater adhesives and the prospects for their biotechnological production.
Protein-based underwater adhesives and the prospects for their biotechnological production.
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DOI：
10.1007/s00253-010-2913-8
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发表时间：
2011-01
影响因子：
5
通讯作者：
Stewart, Russell J.
中科院分区：
文献类型：
--
作者：
Stewart, Russell J.
在过去几十年中，生物技术方法实际生产生物蛋白基粘合剂的成功有限。早期的失望可能限制了生产重组粘附蛋白的更广泛努力。最近的合成聚合物方法已经成功地复制了天然水下粘合剂的某些方面。例如，受贻贝启发的合成聚合物含有3，4-L-二羟基苯丙氨酸的儿茶酚官能团，可牢固地粘附在湿金属氧化物表面上。受Sandcastle蠕虫的启发，合成复合凝聚层是一种水性粘合剂，可以在水下输送而不会分散。合成方法具有几个优点，包括多功能化学和可规模化生产。未来，更复杂的模拟粘合剂可能将联合收割机合成共聚物与重组或农业衍生蛋白质结合，以更好地复制天然粘合剂的结构和功能组织。
Biotechnological approaches to practical production of biological protein-based adhesives have had limited success over the last several decades. Broader efforts to produce recombinant adhesive proteins may have been limited by early disappointments. More recent synthetic polymer approaches have successfully replicated some aspects of natural underwater adhesives. For example, synthetic polymers, inspired by mussels, containing the catecholic functional group of 3,4-L-dihydroxyphenylalanine adhere strongly to wet metal oxide surfaces. Synthetic complex coacervates inspired by the Sandcastle worm are water-borne adhesives that can be delivered underwater without dispersing. Synthetic approaches offer several advantages, including versatile chemistries and scalable production. In the future, more sophisticated mimetic adhesives may combine synthetic copolymers with recombinant or agriculture-derived proteins to better replicate the structural and functional organization of natural adhesives.
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