Score test variable screening.

Score test variable screening.
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得分测试变量筛选。

DOI:
10.1111/biom.12209
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发表时间:
2014-12
期刊:
影响因子:
1.9
通讯作者:
Li Y
Li Y
中科院分区:
数学3区
文献类型:
--
作者:
Zhao SD;Li Y

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Variable screening has emerged as a crucial first step in the analysis of high-throughput data, but existing procedures can be computationally cumbersome, difficult to justify theoretically, or inapplicable to certain types of analyses. Motivated by a high-dimensional censored quantile regression problem in multiple myeloma genomics, this paper makes three contributions. First, we establish a score test-based screening framework, which is widely applicable, extremely computationally efficient, and relatively simple to justify. Secondly, we propose a resampling-based procedure for selecting the number of variables to retain after screening according to the principle of reproducibility. Finally, we propose a new iterative score test screening method which is closely related to sparse regression. In simulations we apply our methods to four different regression models and show that they can outperform existing procedures. We also apply score test screening to an analysis of gene expression data from multiple myeloma patients using a censored quantile regression model to identify high-risk genes.
DOI: 10.1093/bioinformatics/btq600
发表时间: 2011-01-01
期刊: BIOINFORMATICS
影响因子: 5.8
作者:
He, Qianchuan;Lin, Dan-Yu
通讯作者: Lin, Dan-Yu
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