Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
Magnesium metabolism in type 2 diabetes mellitus, metabolic syndrome and insulin resistance
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DOI：
10.1016/j.abb.2006.05.007
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发表时间：
2007-02-01
影响因子：
3.9
通讯作者：
Dominguez, Ligia J.
中科院分区：
文献类型：
--
作者：
Barbagallo, Mario;Dominguez, Ligia J.
2型糖尿病的特征在于细胞和细胞外Mg消耗。流行病学研究表明，糖尿病受试者中低镁血症和细胞内镁浓度较低的患病率较高。胰岛素和葡萄糖是镁代谢的重要调节因子。细胞内镁在调节胰岛素作用、胰岛素介导的葡萄糖摄取和血管张力中起关键作用。细胞内镁浓度降低导致酪氨酸激酶活性缺陷、胰岛素作用的受体后损害和糖尿病患者胰岛素抵抗的恶化。镁缺乏被认为是不同代谢条件下“胰岛素抵抗”的潜在共同机制。饮食镁摄入量低也与2型糖尿病的发展有关。镁补充剂对糖尿病受试者代谢特征的益处已在大多数但并非所有临床研究中发现，需要更大规模的前瞻性研究来支持膳食镁补充剂作为糖尿病风险中可能的公共卫生策略的潜在作用。(c)2006年爱思唯尔公司All rights reserved.
Type 2 diabetes is characterized by cellular and extracellular Mg depletion. Epidemiologic studies showed a high prevalence of hypo-magnesaemia and lower intracellular Mg concentrations in diabetic Subjects. Insulin and glucose are important regulators of Mg metabolism. Intracellular Mg plays a key role in regulating insulin action, insulin-mediated-glucose uptake and vascular tone. Reduced intracellular Mg concentrations result in a defective tyrosine-kinase activity, post-receptorial impairment in insulin action, and worsening of insulin resistance in diabetic patients. Mg deficit has been proposed as a possible underlying common mechanism of the "insulin resistance" of different metabolic conditions. Low dietary Mg intake is also related to the development of type 2 diabetes. Benefits of Mg supplementation on metabolic profile in diabetic subjects have been found in most, but not all clinical studies, and larger prospective studies are needed to support the potential role of dietary Mg supplementation as a possible public health strategy in diabetes risk. (c) 2006 Elsevier Inc. All rights reserved.