Leaping forks at inverted repeats
Leaping forks at inverted repeats
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DOI：
10.1101/gad.1884810
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发表时间：
2010-01-01
影响因子：
10.5
通讯作者：
Foiani, Marco
中科院分区：
文献类型：
--
作者：
Branzei, Dana;Foiani, Marco
基因组重排通常与癌症和其他病理疾病中观察到的基因组不稳定有关。不同类型的重复元素在基因组中很常见，并且容易产生不稳定性。s期检查点、重组和端粒维持途径与抑制染色体重排有关，但对产生这种全基因组不稳定性的分子机制和染色体中间体知之甚少。在2009年12月15日的《基因与发育》杂志上，Paek及其同事（2861-2875）和Mizuno及其同事（2876-2886页）的两项研究表明，出芽酵母和裂变酵母中附近的反向重复序列自发地重组，并经常形成双中心和无中心染色体。这种现象背后的重组机制似乎并不需要双链断裂形成，而可能是由涉及模板切换的复制机制引起的。
Genome rearrangements are often associated with genome instability observed in cancer and other pathological disorders. Different types of repeat elements are common in genomes and are prone to instability. S-phase checkpoints, recombination, and telomere maintenance pathways have been implicated in suppressing chromosome rearrangements, but little is known about the molecular mechanisms and the chromosome intermediates generating such genome-wide instability. In the December 15, 2009, issue of Genes & Development, two studies by Paek and colleagues (2861-2875) and Mizuno and colleagues (pp. 2876-2886), demonstrate that nearby inverted repeats in budding and fission yeasts recombine spontaneously and frequently to form dicentric and acentric chromosomes. The recombination mechanism underlying this phenomenon does not appear to require double-strand break formation, and is likely caused by a replication mechanism involving template switching.