Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct
Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct
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DOI：
10.1007/s00125-013-2899-8
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发表时间：
2013-07-01
期刊：
影响因子：
8.2
通讯作者：
Wareham, N. J.
中科院分区：
文献类型：
--
作者：
Romaguera, D.;Norat, T.;Wareham, N. J.
研究表明，含糖饮料的消费（主要是在美国人群中）会增加2型糖尿病的发病率。我们的目的是评估甜饮料消费的关联（果汁和花蜜，含糖软饮料和人工甜味软饮料）与欧洲成人2型糖尿病发病率的关系。我们建立了一项病例队列研究，包括12,403例2型糖尿病病例和16例分层亚队列，154名参与者选自参加欧洲癌症与营养前瞻性调查（EPIC）研究的8个欧洲队列。排除后，最终样本量包括11，684例事件病例和15，374名参与者的子队列。考克斯比例风险回归模型（修改为病例队列设计）和随机效应荟萃分析被用来估计甜饮料消费量之间的关联，（从经验证的饮食问卷中获得）和2型糖尿病发病率之间的关系。在调整后的模型中，一个336克（12盎司）的每日增量糖-加糖和人工加糖软饮料的消费与2型糖尿病的HR相关，HR为1.22（95% CI 1.09，1.38）和1.52（95% CI 1.26，1.83）。在进一步调整能量摄入和BMI后，含糖软饮料与2型糖尿病的相关性持续存在（HR 1.18，95% CI 1.06，1.32），但人工加糖软饮料的相关性在统计学上不显著（HR 1.11，95% CI 0.95，1.31）。果汁和花蜜的消费与2型糖尿病发病率无关。这项研究证实了欧洲成年人2型糖尿病发病率的增加与高消费含糖软饮料之间的联系。
Consumption of sugar-sweetened beverages has been shown, largely in American populations, to increase type 2 diabetes incidence. We aimed to evaluate the association of consumption of sweet beverages (juices and nectars, sugar-sweetened soft drinks and artificially sweetened soft drinks) with type 2 diabetes incidence in European adults.We established a case-cohort study including 12,403 incident type 2 diabetes cases and a stratified subcohort of 16,154 participants selected from eight European cohorts participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. After exclusions, the final sample size included 11,684 incident cases and a subcohort of 15,374 participants. Cox proportional hazards regression models (modified for the case-cohort design) and random-effects meta-analyses were used to estimate the association between sweet beverage consumption (obtained from validated dietary questionnaires) and type 2 diabetes incidence.In adjusted models, one 336 g (12 oz) daily increment in sugar-sweetened and artificially sweetened soft drink consumption was associated with HRs for type 2 diabetes of 1.22 (95% CI 1.09, 1.38) and 1.52 (95% CI 1.26, 1.83), respectively. After further adjustment for energy intake and BMI, the association of sugar-sweetened soft drinks with type 2 diabetes persisted (HR 1.18, 95% CI 1.06, 1.32), but the association of artificially sweetened soft drinks became statistically not significant (HR 1.11, 95% CI 0.95, 1.31). Juice and nectar consumption was not associated with type 2 diabetes incidence.This study corroborates the association between increased incidence of type 2 diabetes and high consumption of sugar-sweetened soft drinks in European adults.