From tissue mechanics to transcription factors.
From tissue mechanics to transcription factors.
复制标题
DOI：
10.1016/j.diff.2013.07.004
复制
发表时间：
2013-10
期刊：
影响因子：
--
通讯作者：
McCulloch CA
中科院分区：
文献类型：
--
作者：
Janmey PA;Wells RG;Assoian RK;McCulloch CA
组织硬度的变化通常与癌症、纤维化和动脉粥样硬化等疾病相关。最近的几项研究表明，除了由病理学引起之外，机械变化可能在引起疾病进展中发挥类似于可溶性因子的作用，并且类似的机械控制对于正常组织发育和稳态可能是必不可少的。许多细胞类型改变它们的结构和功能以响应外源力或作为它们粘附的材料的机械性质的函数。本文综述了最近的进展，在确定细胞内的信号通路，特别是转录程序，差异激活时，细胞粘附到不同的机械性能的材料，或当他们受到张力所产生的外力。涉及小GTP酶、粘着斑激酶和转化生长因子β以及转录调节因子MRTF-A、NFκB和雅普/Taz的几种细胞质或细胞骨架信号传导途径已成为机械信号传导的重要介质。
Changes in tissue stiffness are frequently associated with diseases such as cancer, fibrosis, and atherosclerosis. Several recent studies suggest that, in addition to resulting from pathology, mechanical changes may play a role akin to soluble factors in causing the progression of disease, and similar mechanical control might be essential for normal tissue development and homeostasis. Many cell types alter their structure and function in response to exogenous forces or as a function of the mechanical properties of the materials to which they adhere. This review summarizes recent progress in identifying intracellular signaling pathways, and especially transcriptional programs, that are differentially activated when cells adhere to materials with different mechanical properties or when they are subject to tension arising from external forces. Several cytoplasmic or cytoskeletal signaling pathways involving small GTPases, focal adhesion kinase and transforming growth factor beta as well as the transcriptional regulators MRTF-A, NFκB, and Yap/Taz have emerged as important mediators of mechanical signaling.