Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids
Release of oxytocin in the rat central amygdala modulates stress-coping behavior and the release of excitatory amino acids
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DOI：
10.1038/sj.npp.1300607
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发表时间：
2005-02-01
影响因子：
7.6
通讯作者：
Neumann, ID
中科院分区：
文献类型：
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作者：
Ebner, K;Bosch, OJ;Neumann, ID
先前的实验表明，催产素（OXT）的释放发生在下丘脑和下丘脑外的各个脑区。在本研究中，我们研究了雄性大鼠游泳应激是否会触发中央杏仁核（CeA）中OXT的释放，这是处理情绪和应激反应的关键区域。此外，我们研究了在强迫游泳过程中，CeA内释放的OXT对行为反应的生理意义，以及对局部释放的特定氨基酸（包括谷氨酸、天冬氨酸、精氨酸、牛磺酸和GABA）的影响，这些氨基酸被认为可以调节情绪的处理。暴露于10分钟的强制游泳时段导致OXT释放显着增加(200%,p
Previous experiments have indicated that the release of oxytocin (OXT) occurs in various hypothalamic and extrahypothalamic brain areas. In the present study, we investigated in male rats whether swim stress triggers the release of OXT in the central amygdala (CeA), a key area in processing emotions and stress responses. Further, we examined the physiological significance of OXT released within the CeA for behavioral responses during forced swimming as well as effects on the local release of selected amino acids including glutamate, aspartate, arginine, taurine, and GABA, which are thought to modulate processing of emotions. Exposure to a 10-min forced swimming session caused a significant increase in OXT release (200%, p