From endophenotypes to evolution: social attachment, sexual fidelity and the avpr1a locus.
From endophenotypes to evolution: social attachment, sexual fidelity and the avpr1a locus.
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从内表型到进化：社会依恋、性忠诚和 avpr1a 基因座。
DOI：
10.1016/j.conb.2010.09.002
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发表时间：
2010
影响因子：
5.7
通讯作者：
Phelps,StevenM
中科院分区：
文献类型：
--
作者：
Phelps,StevenM
医学和进化遗传学都日益强调对表型的微妙、定量测量的重要性。其中一种“内表型”，即血管加压素1a受体(V1aR)的分布，是最近社会行为研究的一个焦点。在动物研究中，V1aR的神经分布与社会依恋和性忠诚模式都有关。在遗传水平上，avpr1a基因顺式调控区域的一个微卫星与大脑和行为的变异有关。随着机制和进化细节被更充分地研究，这两组数据都变得更加复杂。我简要总结了最近动物和人类研究avpr1a的工作，并强调了比较方法和临床方法之间的相似之处。
Both medical and evolutionary genetics increasingly emphasize the importance of subtle, quantitative measures of phenotype. One such ‘endophenotype,’ the distribution of vasopressin 1a receptor (V1aR), is a recent focus for studies of social behavior. In animal studies, the neural distribution of V1aR has been linked to both social attachment and patterns of sexual fidelity. At a genetic level, a microsatellite in the cis-regulatory region of the avpr1a locus has been linked to variation in both brain and behavior. Both sets of data become more complex as the mechanistic and evolutionary details are examined more fully. I briefly summarize recent work from animal and human studies of avpr1a and highlight parallels between comparative and clinical approaches.