Chronic ethanol consumption alters transbilayer distribution of phosphatidylcholine in erythrocytes of Sinclair (S-1) miniature swine.
Chronic ethanol consumption alters transbilayer distribution of phosphatidylcholine in erythrocytes of Sinclair (S-1) miniature swine.
复制标题
慢性乙醇消耗改变辛克莱（S-1）小型猪红细胞中磷脂酰胆碱的跨双层分布。
DOI：
10.1016/0741-8329(91)90648-g
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Schroeder,F
中科院分区：
文献类型：
--
作者：
Wood,WG;Gorka,C;Johnson,JA;Sun,GY;Sun,AY;Schroeder,F
研究了慢性乙醇消耗对辛克莱（S-1）小型猪红细胞外表面和细胞表面小叶磷脂跨双层分布的影响。磷脂酰胆碱（PC）主要位于外表面小叶，磷脂酰乙醇胺（PE）和磷脂酰丝氨酸（PS）主要位于细胞表面小叶。长期乙醇消耗显著增加了外膜小叶PC含量，但未改变大膜PC组成。乙醇引起的PC分布变化是PC所特有的，PE和PS没有发现。乙醇组鞘磷脂也显著减少。鞘磷脂主要是一种外表面磷脂。乙醇诱导的外膜小叶的特异性变化与最近的研究一致，研究表明，与细胞小叶相比，外膜小叶更容易受到乙醇的影响。这种特异性作用为观察乙醇如何改变膜结构和功能提供了一种新的途径。
Effects of chronic ethanol consumption on transbilayer distribution of phospholipids in the exofacial and cytofacial leaflets of erythrocytes from chronic ethanol-consuming Sinclair (S-1) miniature swine were examined. Phosphatidylcholine (PC) was predominantly located in the exofacial leaflet and phosphatidylethanolamine (PE) and phosphatidylserine (PS) located primarily in the cytofacial leaflet. Chronic ethanol consumption significantly increased PC content in the exofacial leaflet without changing bulk membrane PC composition. Ethanol-induced changes in PC distribution were specific for PC and not detected in PE or PS. There was also a significant decrease in sphingomyelin in the ethanol group. Sphingomyelin is primarily an exofacial phospholipid. The specific ethanol-induced changes in the exofacial leaflet are consistent with recent studies showing that the exofacial membrane leaflet is more susceptible to effects of ethanol as compared to the cytofacial leaflet. Such specificity of action provides a new way of viewing how ethanol alters membrane structure and function.