Default mode of brain function in monkeys.
Default mode of brain function in monkeys.
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DOI：
10.1523/jneurosci.2318-11.2011
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发表时间：
2011-09-07
期刊：
影响因子：
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通讯作者：
Vanduffel W
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作者：
Mantini D;Gerits A;Nelissen K;Durand JB;Joly O;Simone L;Sawamura H;Wardak C;Orban GA;Buckner RL;Vanduffel W
人类的神经影像学已经揭示了一个特定的大脑区域网络-默认模式网络（DMN）-在目标导向行为期间会降低其活动。到目前为止，猴子中类似网络的证据主要是间接的，因为除了一项正电子发射断层扫描研究外，所有这些都是基于功能连接分析，而不是被动任务状态下的活动增加。在这里，我们测试了是否一致的DMN存在于猴子使用其定义属性。我们对10只清醒猴子的功能磁共振成像数据进行了荟萃分析，以揭示当任务需求从被动任务转向外部导向处理时活动持续减少的区域。我们在15个实验中观察到与任务相关的空间特异性失活，这意味着猴子的功能相当于人类DMN。我们揭示了静息状态连接，前额叶和内侧顶叶区域，包括9/46 d和31，分别构成DMN核心，功能连接到所有其他DMN领域。我们还发现了两个不同的子系统组成的DMN领域之间的功能连接更强。这些聚类分别包括24/32、8b和TPOC区以及23、v23和PGm区。这种功能连接模式在很大程度上符合，但不完全符合猴子的解剖道跟踪数据。此外，DMN区之间的传入和传出连接的分析表明，多突触网络结构。和人类一样，猴子在异模态和边缘关联区域的被动时期会增加活动，这表明它们在不主动与环境互动时也会默认内部处理模式。
Human neuroimaging has revealed a specific network of brain regions—the default-mode network (DMN)—that reduces its activity during goal-directed behavior. So far, evidence for a similar network in monkeys is mainly indirect, since, except for one positron emission tomography study, it is all based on functional connectivity analysis rather than activity increases during passive task states. Here, we tested whether a consistent DMN exists in monkeys using its defining property. We performed a meta-analysis of functional magnetic resonance imaging data collected in 10 awake monkeys to reveal areas in which activity consistently decreases when task demands shift from passive tasks to externally oriented processing. We observed task-related spatially specific deactivations across 15 experiments, implying in the monkey a functional equivalent of the human DMN. We revealed by resting-state connectivity that prefrontal and medial parietal regions, including areas 9/46d and 31, respectively, constitute the DMN core, being functionally connected to all other DMN areas. We also detected two distinct subsystems composed of DMN areas with stronger functional connections between each other. These clusters included areas 24/32, 8b, and TPOC and areas 23, v23, and PGm, respectively. Such a pattern of functional connectivity largely fits, but is not completely consistent with anatomical tract tracing data in monkeys. Also, analysis of afferent and efferent connections between DMN areas suggests a multisynaptic network structure. Like humans, monkeys increase activity during passive epochs in heteromodal and limbic association regions, suggesting that they also default to internal modes of processing when not actively interacting with the environment.