Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.
Dividing the spoils of growth and the cell cycle: The fission yeast as a model for the study of cytokinesis.
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DOI：
10.1002/cm.20500
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发表时间：
2011-02
期刊：
影响因子：
2.9
通讯作者：
Nakano, Kentaro
中科院分区：
文献类型：
--
作者：
Goya, Anupama;Takaine, Masak;Simanis, Viesturs;Nakano, Kentaro
胞质分裂是细胞周期的最后阶段，确保基因组分离和细胞器分配到子代细胞。胞质分裂需要细胞解决空间问题(在正确的位置分裂，与染色体分离平面垂直)和时间问题(协调胞质分裂和有丝分裂)。胞质分裂的时空控制缺陷可能导致细胞死亡，或增加肿瘤形成的风险[(Fujiwara T，Bandi M，Nitta M，Ivanova EV，Bronson RT，Pellman D.2005)。胞质分裂失败产生的四倍体促进了p53缺失细胞的肿瘤发生。自然437：1043-1047)；由(Ganem NJ，Storchova Z，Pellman D.2007)评审。四倍体、非整倍体和癌症。Curr Opin Genet Dev 17：157-162.)]不对称胞质分裂允许产生形状、大小和性质不同的两个子细胞，在发育过程中以及对多细胞生物体中的细胞内稳态都是重要的[Li R.2007]。发育和疾病中的细胞质分裂：一个共同主题的变化。细胞摩尔生命科学：3044-3058)。本综述的主要焦点是裂殖酵母有丝分裂周期中胞质分裂的机制。这个简单的模型对我们理解细胞周期是如何调节的做出了重大贡献，并成为研究细胞质分裂方面的一个很好的模型。在这里，我们将讨论我们对收缩环如何组装和分解、它如何收缩的知识状况，以及我们对控制这些事件并确保它们与染色体分离相协调的调控机制的了解。©2011 Wiley-Liss，Inc.
Cytokinesis is the final stage of the cell cycle, and ensures completion of both genome segregation and organelle distribution to the daughter cells. Cytokinesis requires the cell to solve a spatial problem (to divide in the correct place, orthogonally to the plane of chromosome segregation) and a temporal problem (to coordinate cytokinesis with mitosis). Defects in the spatiotemporal control of cytokinesis may cause cell death, or increase the risk of tumor formation [ (Fujiwara T, Bandi M, Nitta M, Ivanova EV, Bronson RT, Pellman D. 2005. Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells. Nature 437:1043–1047); reviewed by (Ganem NJ, Storchova Z, Pellman D. 2007. Tetraploidy, aneuploidy and cancer. Curr Opin Genet Dev 17:157–162.)]. Asymmetric cytokinesis, which permits the generation of two daughter cells that differ in their shape, size and properties, is important both during development, and for cellular homeostasis in multicellular organisms [reviewed by (Li R. 2007. Cytokinesis in development and disease: variations on a common theme. Cell Mol Life Sci 64:3044–3058)]. The principal focus of this review will be the mechanisms of cytokinesis in the mitotic cycle of the yeast Schizosaccharomyces pombe. This simple model has contributed significantly to our understanding of how the cell cycle is regulated, and serves as an excellent model for studying aspects of cytokinesis. Here we will discuss the state of our knowledge of how the contractile ring is assembled and disassembled, how it contracts, and what we know of the regulatory mechanisms that control these events and assure their coordination with chromosome segregation. © 2011 Wiley-Liss, Inc.
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DOI：
10.1083/jcb.143.6.1603
发表时间：
1998-12-14
期刊：
The Journal of cell biology
影响因子：
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作者：
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10.1083/jcb.111.5.1905
发表时间：
1990-11
期刊：
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