Garcinol Reduces Obesity in High-Fat-Diet-Fed Mice by Modulating Gut Microbiota Composition
Garcinol Reduces Obesity in High-Fat-Diet-Fed Mice by Modulating Gut Microbiota Composition
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DOI：
10.1002/mnfr.201800390
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发表时间：
2019-01-01
影响因子：
5.2
通讯作者：
Pan, Min-Hsiung
中科院分区：
文献类型：
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作者：
Lee, Pei-Sheng;Teng, Chia-Yi;Pan, Min-Hsiung
范围 肥胖已成为世界范围内的一个主要健康问题，并与低度慢性炎症和肠道菌群失调有关。本研究旨在研究藤黄酚（Garcinol）的化学预防作用，藤黄酚是一种从藤黄果皮中分离出来的聚异戊二烯化二苯甲酮衍生物。描述了藤黄醇如何防止高脂饮食 (HFD) 诱导的小鼠肥胖，并确定其抗肥胖作用是否与肠道微生物群有关。方法和结果结果表明，藤黄醇以剂量依赖的方式减少高脂饮食小鼠的体重增加和相对内脏脂肪组织脂肪重量。此外，山竹酚显着降低谷氨酸丙酮酸转氨酶、总胆固醇和三酰甘油的血浆水平。 16S rRNA 基因序列数据表明，garcinol 不仅可以逆转 HFD 诱导的肠道生态失调（厚壁菌门与拟杆菌门比例下降表明），而且还可以通过增加肠道共生菌 Akkermansia 来控制炎症。此外，参与脂肪细胞脂肪生成的 AMP 激活蛋白激酶 α 信号通路也受到 Garcinol 的影响。结论 综上所述，这些结果首次证明山竹酚可以预防 HFD 引起的肥胖，并可作为一种新型肠道菌群调节剂来预防 HFD 引起的肠道菌群失调和肥胖相关的代谢紊乱。
Scope Obesity has become a major health problem worldwide and is associated with low-grade chronic inflammation and intestinal dysbiosis. This study is conducted to investigate the chemopreventive effects of garcinol, a polyisoprenylated benzophenone derivative isolated from the fruit rind of Garcinia indica. How garcinol protects against obesity in high-fat diet (HFD)-induced mice is delineated and whether its anti-obesity effects are related to gut microbiota has been determined. Methods and results The results show that garcinol reduces HFD-fed mice body weight gain and relative visceral adipose tissue fat weight in a dose-dependent manner. Furthermore, garcinol markedly reduces the plasma levels of glutamate pyruvate transaminase, total cholesterol, and triacylglycerol. The 16S rRNA gene sequence data indicate that garcinol not only reverses HFD-induced gut dysbiosis-as indicated by the decreased Firmicutes-to-Bacteroidetes ratios-but also controls inflammation by increasing the intestinal commensal bacteria, Akkermansia. In addition, the AMP-activated protein kinase alpha signaling pathway involved in adipocyte adipogenesis is also affected by garcinol. Conclusion Taken together, these results demonstrate for the first time that garcinol can prevent HFD-induced obesity and may be used as a novel gut microbiota modulator to prevent HFD-induced gut dysbiosis and obesity-related metabolic disorders.