ELONGATED PHOTORECEPTOR OUTER SEGMENT LENGTH AND PROGNOSIS OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
ELONGATED PHOTORECEPTOR OUTER SEGMENT LENGTH AND PROGNOSIS OF CHRONIC CENTRAL SEROUS CHORIORETINOPATHY
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DOI：
10.1097/iae.0000000000002445
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发表时间：
2020-04-01
影响因子：
3.3
通讯作者：
Obata, Ryo
中科院分区：
文献类型：
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作者：
Asano, Kimiko Shimizu;Asaoka, Ryo;Obata, Ryo
目的：评估延长的感光细胞外段长度对慢性中心性浆液性脉络膜视网膜病变患者接受半剂量半通量光动力疗法（减少PDT）治疗后视力预后的影响。研究方法：该研究包括36例慢性中心性浆液性脉络膜视网膜病变患者的36只眼，他们接受了减少的PDT，并随访至少1年。在基线和减少PDT后12个月进行光谱域光学相干断层扫描测量。此后，评估减少PDT后12个月的最佳矫正视力（BCVA）与7个基线变量（年龄、症状持续时间、BCVA、外核层厚度、延长的感光细胞外段长度、视网膜下脱离高度和中心凹下脉络膜厚度）之间的相关性。使用校正的Akaike信息标准指数进行模型选择的多变量分析。结果如下：12个月时BCVA的最佳模型仅包括基线BCVA（系数= 0.90，P < 0.0001）和基线延长的感光细胞外段长度（系数=-0.0016，P = 0.034），而不包括外核层厚度。结论：延长的感光细胞外段长度与减少PDT治疗后慢性中心性浆液性脉络膜视网膜病变患者的BCVA预后显著相关，并可用于预测慢性中心性浆液性脉络膜视网膜病变活动期的残余感光细胞功能。
Purpose: To evaluate the effect of elongated photoreceptor outer segment length on the visual prognosis of patients with chronic central serous chorioretinopathy after treatment using half-dose and half-fluence photodynamic therapy (reduced PDT). Methods: The study included 36 eyes of 36 patients with chronic central serous chorioretinopathy who underwent reduced PDT and were followed up for at least 1 year. Spectral domain optical coherence tomography measurement was conducted at baseline and 12 months after reduced PDT. Thereafter, the association between the best-corrected visual acuity (BCVA) at 12 months after reduced PDT and 7 baseline variables (age, symptom duration, BCVA, outer nuclear layer thickness, elongated photoreceptor outer segment length, height of subretinal detachment, and subfoveal choroidal thickness) was evaluated. Multivariate analyses using the model selection with the corrected Akaike Information Criterion index were performed. Results: The optimal model for BCVA at 12 months only included baseline BCVA (coefficient = 0.90, P < 0.0001) and baseline elongated photoreceptor outer segment length (coefficient = -0.0016, P = 0.034), but not outer nuclear layer thickness. Conclusion: Elongated photoreceptor outer segment length was significantly associated with BCVA prognosis in patients with chronic central serous chorioretinopathy after reduced PDT and can be useful for predicting residual photoreceptor function during the active phase of chronic central serous chorioretinopathy.