Enduring changes in dopamine receptor cells of pups from drug administration to pregnant and nursing rats.
Enduring changes in dopamine receptor cells of pups from drug administration to pregnant and nursing rats.
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DOI：
10.1126/science.570724
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发表时间：
1979-03
期刊：
影响因子：
56.9
通讯作者：
H. Rosengarten;A. Friedhoff
中科院分区：
文献类型：
--
作者：
H. Rosengarten;A. Friedhoff
在妊娠期间用氟哌啶醇或α-甲基-p-酪氨酸甲酯处理的大鼠母亲的后代中观察到特异性[3 H]螺哌啶与大鼠尾状体组织结合的减少和对阿朴吗啡引起刻板行为的敏感性的平行降低。相比之下，如果在哺乳期而不是妊娠期对其母亲产后给予氟哌啶醇，则在幼仔中观察到多巴胺受体敏感性增加的证据。
A decrease in specific [3H]spiroperidol binding to rat caudate tissue and a parallel decrease in sensitivity to apomorphine in eliciting stereotyped behavior was observed in the offspring of rat mothers treated with either haloperidol or alpha-methyl-p-tyrosine-methyl ester during pregnancy. In contrast, evidence of increased dopamine-receptor sensitivity was observed in the pups if haloperidol was administered to their mothers postpartum during nursing rather than during pregnancy.