PULMONARY COMPLICATIONS IN PATIENTS WITH ADULT T-CELL LEUKEMIA
PULMONARY COMPLICATIONS IN PATIENTS WITH ADULT T-CELL LEUKEMIA
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DOI：
10.1002/1097-0142(19850515)55:10
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发表时间：
1985-01-01
期刊：
影响因子：
6.2
通讯作者：
TAKATSUKI, K
中科院分区：
文献类型：
--
作者：
YOSHIOKA, R;YAMAGUCHI, K;TAKATSUKI, K
一项对360例各种血液病患者的调查显示，成人T细胞白血病（ATL）患者的呼吸并发症发生率高于其他患者。29例ATL患者中有26例出现肺部并发症；白血病肺浸润13例，出血1例，间质性肺炎1例，肺部感染13例。尽管中性粒细胞计数充足，卡氏肺囊虫和细菌性肺炎的发病率仍然很高。即使在慢性和阴燃性ATL中，呼吸系统疾病的发生率也很高。其中许多是白血病细胞浸润。13例肺浸润患者中有10例发生在早期，6例在ATL诊断前被诊断为“慢性肺病”。组织学上几乎所有病例均伴有或多或少程度的纤维化。经支气管肺活检（TBLB）对诊断有价值（13例中有8例）。
A survey of 360 patients with various hematologic diseases revealed a high frequency of respiratory complications in patients with adult T cell leukemia (ATL) compared to others. Among 29 patients with ATL, pulmonary complications were seen in 26 patients; leukemic pulmonary infiltration in 13, bleeding in 1, interstitial pneumonitis in 1 and pulmonary infection in 13. The incidence of Pneumocystis carinii and bacterial pneumonias were high despite adequate neutrophil count. Even in chronic and smoldering ATL, respiratory diseases were found in high frequency. Many of those were leukemic cell infiltration. In 10 of 13 patients with pulmonary infiltration, it occurred in the early stage and 6 were diagnosed as having "chronic lung disease" before the diagnosis of ATL. Its histology was accompanied by fibrosis in greater or lesser degree in almost all cases. Transbroncheal lung biopsy (TBLB) is of value in diagnosis (8 of 13 cases).