Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population
Screening for two SNPs of LINGO1 gene in patients with essential tremor or sporadic Parkinson's disease in Chinese population
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中国人群原发性震颤或散发性帕金森病患者LINGO1基因2个SNPs的筛选
DOI：
10.1016/j.neulet.2010.06.041
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发表时间：
2010-09-06
影响因子：
2.5
通讯作者：
Tang, Bei-sha
中科院分区：
文献类型：
--
作者：
Zuo, Xing;Jiang, Hong;Tang, Bei-sha
位于LINGO1基因内含子3的两个标记rs9652490和rs11856808最近被提名为与特发性震颤（ET）相关。虽然ET和帕金森病（PD）被认为是不同的实体，但它们有许多重叠的临床和病理特征。我们的目的是评估rs9652490和rs11856808在ET和PD发展中的作用。为此，我们对109例ET患者、425例散发性帕金森病（SPD）患者和430例对照者的两个标记物的区域进行了测序。在按年龄分层后，rs9652490G等位基因提示在早发性PD（EOPD，发病年龄）中具有保护作用
Two markers rs9652490 and rs11856808 both located in intron 3 of the LINGO1 gene have been nominated recently to be associated with essential tremor (ET). Although ET and Parkinson's disease (PD) are considered as different entities, they have many overlapping clinical and pathological features. We aimed to evaluate the role of rs9652490 and rs11856808 in the development of ET and PD. To this point, we sequenced the region involving the two markers in 109 ET cases, 425 sporadic Parkinson's disease (SPD) cases and 430 controls in Chinese population. After stratification by age, the rs9652490G allele suggested protective role in the early onset PD (EOPD, age at onset