De Novo Synthesis of Racemic 4‐Deoxy‐4,4‐difluoro‐ and 2,4‐Dideoxy‐2,4,4‐trifluorohexosides
De Novo Synthesis of Racemic 4‐Deoxy‐4,4‐difluoro‐ and 2,4‐Dideoxy‐2,4,4‐trifluorohexosides
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外消旋4-脱氧-4,4-二氟-和2,4-二脱氧-2,4,4-三氟己糖苷的从头合成
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
V. Gouverneur
中科院分区：
文献类型：
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作者：
G. Giuffredi;B. Bernet;V. Gouverneur
A range of racemic 4-deoxy-4,4-difluorinated carbohydrates were prepared by using a diversity-oriented de novo synthesis starting with three commercially available two-carbon building blocks. A common gem-difluorinated glycal was prepared in 35 % yield in seven steps, from which five different 4-deoxy-4,4-difluoro- and 4-deoxy-2,4,4-trifluorohexopyranosides were accessed using well-established functional group manipulations.
