At-home testing to mitigate community transmission of SARS-CoV-2: protocol for a public health intervention with a nested prospective cohort study.
At-home testing to mitigate community transmission of SARS-CoV-2: protocol for a public health intervention with a nested prospective cohort study.
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DOI：
10.1186/s12889-021-12007-w
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发表时间：
2021-12-04
影响因子：
4.5
通讯作者：
Corbie-Smith G
中科院分区：
文献类型：
--
作者：
Ciccone EJ;Conserve DF;Dave G;Hornik CP;Kuhn ML;Herling JL;Song M;Alston S;Singler L;Schmidt MD;Jones A;Broderick S;Wruck LM;Kibbe WA;Aiello AE;Woods CW;Richmond A;Cohen-Wolkowiez M;Corbie-Smith G
由严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)引起的新冠肺炎大流行继续演变为一种全球卫生危机。尽管已经开发出高效疫苗，但非药物干预对控制疾病传播仍然至关重要。一种这样的干预--快速、在家进行抗原自我检测--可以减轻与基于设施的检测计划相关的负担，并改善高危社区的检测途径。然而，它对SARS-CoV-2社区传播的影响尚未得到明确的评估，在服务不足的人群中进行检测的社会行为方面仍然未知。作为由美国国立卫生研究院资助的快速加速诊断服务不足人群(RADx-UP)计划的一部分，我们正在实施一项名为“说是！在北卡罗来纳州(格林维尔，皮特县)和田纳西州(查塔努加市，汉密尔顿县)进行的“冠状病毒检测”(SYCT)包括使用SARS-CoV-2快速抗原分析进行的家庭自检。这项干预得到了多方面的沟通和社区参与战略的支持，以确保广泛的认识和接受，特别是在边缘化社区。参与者通过在线订购或通过当地社区分销合作伙伴收到测试套件。为了评估这项干预措施对SARS-CoV-2传播的影响，我们将利用社区水平的结果进行一项非随机的生态研究。具体地说，我们将评估在SYCT干预之前、期间和之后每个社区的SARS-CoV-2病例和住院情况、废水中的SARS-CoV-2病毒载量以及人口流动性的趋势。选择参加SYCT的个人还可以选择参加一项嵌入式前瞻性队列研究，收集参与者水平的数据，以评估家庭自我检测的行为决定因素和SARS-CoV-2社区传播的社会行为机制。这是美国第一次大规模的公共卫生干预，实施快速的家庭SARS-CoV-2自我检测。该计划包括一项新颖的家庭测试计划、广泛的沟通和社区参与战略、评估影响的生态研究以及测试行为方面的研究子研究。SYCT项目的发现将为减少病毒传播的创新方法提供见解，促进公共卫生传播和社区参与的科学，并评估新出现的对社区疾病传播的评估。网上版载有补充材料，可在10.1186/s12889-021-12007-w查阅。
The COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to evolve as a global health crisis. Although highly effective vaccines have been developed, non-pharmaceutical interventions remain critical to controlling disease transmission. One such intervention—rapid, at-home antigen self-testing—can ease the burden associated with facility-based testing programs and improve testing access in high-risk communities. However, its impact on SARS-CoV-2 community transmission has yet to be definitively evaluated, and the socio-behavioral aspects of testing in underserved populations remain unknown. As part of the Rapid Acceleration of Diagnostics–Underserved Populations (RADx-UP) program funded by the National Institutes of Health, we are implementing a public health intervention titled “Say Yes! COVID Test” (SYCT) involving at-home self-testing using a SARS-CoV-2 rapid antigen assay in North Carolina (Greenville, Pitt County) and Tennessee (Chattanooga City, Hamilton County). The intervention is supported by a multifaceted communication and community engagement strategy to ensure widespread awareness and uptake, particularly in marginalized communities. Participants receive test kits either through online orders or via local community distribution partners. To assess the impact of this intervention on SARS-CoV-2 transmission, we will conduct a non-randomized, ecological study using community-level outcomes. Specifically, we will evaluate trends in SARS-CoV-2 cases and hospitalizations, SARS-CoV-2 viral load in wastewater, and population mobility in each community before, during, and after the SYCT intervention. Individuals who choose to participate in SYCT will also have the option to enroll in an embedded prospective cohort substudy gathering participant-level data to evaluate behavioral determinants of at-home self-testing and socio-behavioral mechanisms of SARS-CoV-2 community transmission. This is the first large-scale, public health intervention implementing rapid, at-home SARS-CoV-2 self-testing in the United States. The program consists of a novel combination of an at-home testing program, a broad communications and community engagement strategy, an ecological study to assess impact, and a research substudy of the behavioral aspects of testing. The findings from the SYCT project will provide insights into innovative methods to mitigate viral transmission, advance the science of public health communications and community engagement, and evaluate emerging, novel assessments of community transmission of disease. The online version contains supplementary material available at 10.1186/s12889-021-12007-w.
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DOI：
10.1016/j.ijid.2020.10.066
发表时间：
2021-01
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Bo Y;Guo C;Lin C;Zeng Y;Li HB;Zhang Y;Hossain MS;Chan JWM;Yeung DW;Kwok KO;Wong SYS;Lau AKH;Lao XQ
通讯作者：
Lao XQ
影响因子：
10.4
作者：
Marvel SW;House JS;Wheeler M;Song K;Zhou YH;Wright FA;Chiu WA;Rusyn I;Motsinger-Reif A;Reif DM
通讯作者：
Reif DM
影响因子：
13.8
作者：
Thompson HS;Manning M;Mitchell J;Kim S;Harper FWK;Cresswell S;Johns K;Pal S;Dowe B;Tariq M;Sayed N;Saigh LM;Rutledge L;Lipscomb C;Lilly JY;Gustine H;Sanders A;Landry M;Marks B
通讯作者：
Marks B
影响因子：
64.8
作者：
Planas, Delphine;Veyer, David;Schwartz, Olivier
通讯作者：
Schwartz, Olivier
DOI：
10.1056/nejmoa2108891
发表时间：
2021-08-12
期刊：
The New England journal of medicine
影响因子：
--
作者：
Lopez Bernal J;Andrews N;Gower C;Gallagher E;Simmons R;Thelwall S;Stowe J;Tessier E;Groves N;Dabrera G;Myers R;Campbell CNJ;Amirthalingam G;Edmunds M;Zambon M;Brown KE;Hopkins S;Chand M;Ramsay M
通讯作者：
Ramsay M