Ghrelin and vascular protection.
Ghrelin and vascular protection.
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DOI：
10.1530/vb-19-0024
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发表时间：
2019-01-01
期刊：
影响因子：
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通讯作者：
Schwenke, Daryl O
中科院分区：
文献类型：
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作者：
Pearson, James T;Shirai, Mikiyasu;Schwenke, Daryl O
Ghrelin是一种小分子肽，在调节食欲、肠道运动、葡萄糖稳态以及心血管保护等方面具有重要作用。这篇综述强调了酰基ghrelin通过维持血管舒张-血管收缩因子的平衡，抑制炎性细胞因子的产生和免疫细胞向血管损伤部位的募集以及促进血管生成来维持正常内皮功能的作用。
Ghrelin is a small peptide with important roles in the regulation of appetite, gut motility, glucose homeostasis as well as cardiovascular protection. This review highlights the role that acyl ghrelin plays in maintaining normal endothelial function by maintaining the balance of vasodilator-vasoconstrictor factors, inhibiting inflammatory cytokine production and immune cell recruitment to sites of vascular injury and by promoting angiogenesis.