Activation and manipulation of host responses by a Gram-positive bacterium
Activation and manipulation of host responses by a Gram-positive bacterium
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革兰氏阳性菌对宿主反应的激活和操纵
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发表时间：
2008
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通讯作者：
G. Sessa
中科院分区：
文献类型：
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作者：
V. Balaji;G. Sessa
番茄植株与Clavibacter michiganensis subsp. Michiganensis（Cmm）代表了研究革兰氏阳性细菌的毒力决定因子与作物抵抗病原体入侵的尝试之间的相互作用的模式病理系统。为了研究植物在这种兼容的相互作用过程中激活的反应，我们最近分析了番茄茎感染Cmm的基因表达谱。该分析揭示了通常在植物感知病原体相关分子模式时观察到的基础防御反应的激活。此外，Cmm感染上调了与乙烯合成和反应相关的宿主基因的表达。对乙烯感知和产生受损的番茄植株的进一步分析表明，乙烯在疾病症状的发展中起重要作用。在这里，我们讨论了可能的分子策略所使用的植物，以识别Cmm感染和可能的机制所采用的病原体干扰植物防御反应的激活和促进疾病。增编：Balaji V，Mayrose M，Sherf O，Jacob-Hirsch J，Eichenlaub R，Rishki N，Manulis-Sasson S，Rechavi G，Barash I，Sessa G.番茄对Clavibacter michiganensis subsp. Michiganensis揭示了乙烯在疾病发展中的作用。植物生理学2008;出版中。
The interaction between tomato plants and Clavibacter michiganensis subsp. michiganensis (Cmm) represents a model pathosystem to study the interplay between the virulence determinants of a Gram-positive bacterium and the attempt of a crop plant to counteract pathogen invasion. To investigate plant responses activated during this compatible interaction, we recently analyzed gene expression profiles of tomato stems infected with Cmm. This analysis revealed activation of basal defense responses that are typically observed upon plant perception of pathogen-associated molecular patterns. In addition, Cmm infection upregulated the expression of host genes related to ethylene synthesis and response. Further analysis of tomato plants impaired in ethylene perception and production demonstrated an important role for ethylene in the development of disease symptoms. Here we discuss possible molecular strategies used by the plant to recognize Cmm infection and possible mechanisms employed by the pathogen to interfere with the activation of plant defense responses and promote disease. Addendum to: Balaji V, Mayrose M, Sherf O, Jacob-Hirsch J, Eichenlaub R, Iraki N, Manulis-Sasson S, Rechavi G, Barash I, Sessa G. Tomato transcriptional changes in response to Clavibacter michiganensis subsp. michiganensis reveal a role for ethylene in disease development. Plant Physiol 2008; In press.