Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria.
Factors associated with severe preeclampsia and eclampsia in Jahun, Nigeria.
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DOI：
10.2147/ijwh.s47056
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Grais RF
中科院分区：
文献类型：
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作者：
Guerrier G;Oluyide B;Keramarou M;Grais RF
探讨传统草药作为尼日利亚严重先兆子痫和子痫的潜在危险因素。我们从2010年10月至2011年5月进行了一项回顾性病例对照研究。病例均为研究期间入住Jahun医院的患有严重先兆子痫或子痫的孕妇以及22周后正常妊娠的妇女。研究期间，共有 1,257 名女性 (44%) 被记录为正常妊娠，419 名 (16%) 女性患有严重先兆子痫/子痫（175 名患有严重先兆子痫，244 名患有子痫）。与严重先兆子痫/子痫风险较高相关的危险因素包括先兆子痫个人史（比值比 [OR] = 21.5；P < 0.001）、既往高血压个人史（OR = 10.5；P < 0.001）、初产（OR = 2.5；P = 0.001）、家庭主妇职业（OR = 1.9；P < 0.001）。 P = 0.008），产前检查次数少于四次（OR = 1.6；P = 0.02）。仅通过单变量分析，妊娠期间使用传统治疗与发生严重先兆子痫/子痫的较高风险相关（OR = 1.6 95%；置信区间 [CI]：1.2–2.1）。使用传统治疗会增加咨询官方卫生部门之前的延误，这可能是有害行为的标志。基于社区的研究可以提供有关该人群草药疗法实践的更多信息。
To explore traditional herbal medicines as potential risk factors of severe preeclampsia and eclampsia in Nigeria. We conducted a retrospective case-control study from October 2010 to May 2011. The cases were all pregnant women admitted to the Jahun Hospital during the study period with severe preeclampsia or eclampsia and women presenting with normal pregnancy after 22 weeks. During the study period, a total of 1,257 women (44%) were recorded as having normal pregnancy, and 419 (16%) women had severe preeclampsia/eclampsia (175 with severe preeclampsia and 244 with eclampsia). The risk factors found to be associated with a greater risk of severe preeclampsia/eclampsia included personal history of preeclampsia (odds ratio [OR] = 21.5; P < 0.001), personal history of preexisting hypertension (OR = 10.5; P < 0.001), primiparity (OR = 2.5; P = 0.001), occupation as housewife (OR = 1.9; P = 0.008), and fewer than four antenatal care visits (OR = 1.6; P = 0.02). Use of traditional treatments during pregnancy was associated with a higher risk of developing severe preeclampsia/eclampsia (OR = 1.6 95%; confidence interval [CI]: 1.2–2.1) by univariate analysis only. Use of traditional treatment, which increases delays before consulting the official health sector, might be a marker for harmful behavior. Community-based studies could provide additional information on the practice of herbal therapy in this population.