TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection.
TLRs, Treg, and B Cells, an Interplay of Regulation during Helminth Infection.
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DOI：
10.3389/fimmu.2012.00008
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发表时间：
2012
影响因子：
7.3
通讯作者：
Layland LE
中科院分区：
文献类型：
--
作者：
Ludwig-Portugall I;Layland LE
寄生虫感染通常被称为调控大师，它为我们了解免疫系统的复杂性提供了一个迷人的视角。与许多其他病原体一样，蠕虫已经发展出复杂的逃避策略，宿主的免疫反应必须在引起严重损害以消除寄生虫或限制损害从而接受感染之间找到平衡。然而，人们不应忘记，这些感染仍然构成严重的公共卫生问题，并可能导致个人严重毁容或死亡。蠕虫操纵宿主反应的一个有趣的副产品是明显预防自身免疫性疾病或过敏，尽管实际机制尚不清楚。众所周知，toll样受体（TLR）和非TLR PRRs在启动先天免疫反应中发挥关键作用，进而产生适当的适应性免疫反应。蠕虫由多种（糖）蛋白和（糖）脂质组成，其中一些已被证明可以触发TLR，或改变TLR介导的反应。这些反应当然也会改变适应性免疫。本文将对蠕虫抗原触发tlr的后果以及对B细胞和调节性T细胞（Treg）行为的下游影响进行综述。
Commonly described as masters of regulation parasitic helminth infections provide a fascinating insight into the complexity of our immune system. As with many other pathogens helminths have developed complex evasion strategies and the immune response of the host has to find a balance between eliciting severe damage to eliminate the parasite or limiting damage and thereby accepting the infection. Nevertheless, one should not forget that these infections still pose a serious public health problem and can elicit severe disfigurement or death in the individual. An interesting spin-off of helminth manipulation on host responses is the apparent prevention of autoimmune diseases or allergy although the actual mechanisms remain unclear. It is well known that Toll-like-receptors (TLR) and non-TLR PRRs play a critical role in initiating innate immune responses which in turn create appropriate adaptive immune reactions. Helminths comprise of a multitude of (glyco)-proteins and (glyco)-lipids and some have been shown to trigger TLR, or alter TLR-mediated responses. Such reactions of course alter adaptive immunity as well. This review will address the consequences of TLR-triggering by helminth antigens and the downstream effect on B cell and regulatory T cell (Treg) actions.
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DOI：
10.1084/jem.20101074
发表时间：
2010-10-25
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Grainger JR;Smith KA;Hewitson JP;McSorley HJ;Harcus Y;Filbey KJ;Finney CA;Greenwood EJ;Knox DP;Wilson MS;Belkaid Y;Rudensky AY;Maizels RM
通讯作者：
Maizels RM
影响因子：
4.4
作者：
Hoffmann, KF;Cheever, AW;Wynn, TA
通讯作者：
Wynn, TA
影响因子：
3.1
作者：
Blackwell, NM;Else, KJ
通讯作者：
Else, KJ
影响因子：
4.8
作者：
Aksoy, E;Zouain, CS;Trottein, F
通讯作者：
Trottein, F
影响因子：
32.4
作者：
Hall, Jason A.;Bouladoux, Nicolas;Sun, Cheng Ming;Wohlfert, Elizabeth A.;Blank, Rebecca B.;Zhu, Qing;Grigg, Michael E.;Berzofsky, Jay A.;Belkaid, Yasmine
通讯作者：
Belkaid, Yasmine