The artificial pancreas
The artificial pancreas
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DOI：
10.1081/bio-120020169
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Benedetti, MM
中科院分区：
文献类型：
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作者：
Brunetti, P;Federici, MO;Benedetti, MM
1型糖尿病的胰岛素分泌绝对不足，需要外源性胰岛素供应来保证患者的生命，避免酮症酸中毒昏迷，并预防糖尿病的慢性并发症。为了获得更符合生理学的替代疗法，自 70 年代初以来一直在寻求不同的方法来制造人造可穿戴胰腺，能够根据连续监测确定的血糖值输送胰岛素。四个组件被认为对于实现人工胰腺至关重要：采样。系统、葡萄糖传感器、用于计算胰岛素剂量的数学模型和相关算法以及用于胰岛素输送的输注系统。目前尚未解决的问题主要是可靠的连续血糖监测和控制算法的可用性，而新技术允许系统小型化。
In type 1 diabetes an absolute deficiency of insulin secretion requires exogenous insulin supply to guarantee the patient's life avoiding ketoacidotic coma and to prevent the chronic complications of diabetes. In order to obtain a more physiological replacement therapy different approaches have been pursued since the early 70s to create an artificial wearable pancreas able to deliver insulin according to the blood glucose values as determined by continuous monitoring. Four components are considered essential for the realisation of an artificial pancreas: the sampling. system, the glucose sensor, the mathematical models and the related algorithms for the calculation of the insulin doses and the infusion system for the insulin delivery. At present the still unsolved issues are mainly represented by the availability of reliable continuous glucose monitor and control algorithms, while the new technologies allow for the miniaturisation of the system.