Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection.
Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection.
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作者：
Host immune responses, including the characteristic influx of neutrophils, against Neisseria gonorrhoeae are poorly understood; adaptive immunity is minimal and nonprotective. We hypothesize that N. gonorrhoeae selectively elicits Th17-dependent responses which recruit innate defense mechanisms including neutrophils and antimicrobial proteins that it can resist. We found that N. gonorrhoeae induced production of IL-17 in mouse T cells and of Th17-inducing cytokines in mouse and human antigen-presenting cells in vitro. IL-17 was induced in the iliac lymph nodes in vivo in a female mouse model of genital tract gonococcal infection. Antibody blockade of IL-17 or deletion of the major IL-17 receptor in IL-17RA-knockoutmice led to prolonged infection and diminished neutrophil influx. Genital tract tissue from IL-17RA-knockout mice showed reduced production of neutrophil-attractant chemokines in response to culture with N. gonorrhoeae. These results imply a crucial role for IL-17 and Th17 cells in the immune response to N. gonorrhoeae.
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DOI：
10.1084/jem.186.2.247
发表时间：
1997-07-21
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Naumann M;Wessler S;Bartsch C;Wieland B;Meyer TF
通讯作者：
Meyer TF
影响因子：
30.5
作者：
LeibundGut-Landmann, Salome;Gross, Olaf;Sousa, Caetano Reis e
通讯作者：
Sousa, Caetano Reis e
影响因子：
3.1
作者：
Fichorova, RN;Desai, PJ;Genco, CA
通讯作者：
Genco, CA
影响因子：
3.1
作者：
NOBLE, RC;KIRK, NM;SOMES, GW
通讯作者：
SOMES, GW
影响因子：
6.4
作者：
Huang, WT;Na, L;Schwarzenberger, P
通讯作者：
Schwarzenberger, P