Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines.
Copper-catalyzed radical cascade cyclization for the synthesis of phosphorated indolines.
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DOI：
10.1039/c4cc10267c
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发表时间：
2015-02
影响因子：
4.9
通讯作者：
Hong-yu Zhang;L. Mao;Bin Yang;Shangdong Yang
中科院分区：
文献类型：
--
作者：
Hong-yu Zhang;L. Mao;Bin Yang;Shangdong Yang
通过铜催化的自由基级联环化反应，发展了一种新的、简便的合成各种含磷吲哚的方法。该反应以廉价的铜为催化剂，K2S2O8为氧化剂，反应条件温和。各种烯烃和P-自由基前驱体与这种转化是相容的。初步的机理研究表明，P-自由基的加入可能会引发反应，然后可能会发生氧化环化反应以得到所需的产物。
A novel and convenient approach to the synthesis of various phosphorated indolines via a copper-catalyzed radical cascade cyclization reaction has been developed. The reaction employs cheap copper as the catalyst and K2S2O8 as the oxidant under mild conditions. Various alkenes and P-radical precursors are compatible with this transformation. Preliminary mechanistic studies reveal that the addition of the P-radical may initiate the reaction, and then oxidative cyclization may be achieved to afford the desired product.