Sexual Experience Interacts with Steroid Exposure to Shape the Partner Preferences of Rats
Sexual Experience Interacts with Steroid Exposure to Shape the Partner Preferences of Rats
复制标题
性体验与类固醇暴露相互作用，塑造老鼠的伴侣偏好
作者：
J. Woodson;B. Balleine;R. Gorski
一项为期三个阶段的实验对断奶后单独饲养的雌性大鼠（围产期和成年期）的性经验和激素暴露进行了控制，以限制青春期周围的社会和性经验。在性经验前后分别测量雄性或发情雌性大鼠的非接触性伴侣偏好，首先是在循环丙酸睾酮（TP）的影响下，然后是在卵巢激素（苯甲酸雌二醇和黄体酮；EB和P）的刺激下。当植入TP胶囊并在性幼稚时进行测试时，所有组的雌性大鼠都更喜欢雌性而不是雄性，没有统计学差异。然而，在与发情的雌性进行了三次性体验之后，男性化组和对照组之间在女性导向偏好的程度上出现了差异，男性化的雌性对发情的雌性表现出明显更大的偏好。与雄性大鼠在EB和P下的性经验没有导致任何组的偏好发生显著变化。组织学评估表明，出生后暴露于TP后，性二态核的视前区（SDN-POA）体积增加，SDN-POA体积与伴侣偏好得分呈正相关，但仅在成年期性经历和循环TP暴露的大鼠中呈正相关。这些结果表明，性经验与类固醇暴露相互作用，形成伴侣偏好。
A three-phase experiment manipulated sexual experience and hormone exposure (perinatally and in adulthood) in female rats housed individually from weaning so as to limit peripubertal social and sexual experience. Noncontact partner preference for a male or estrous female rat was measured both before and after sexual experience, first while rats were under the influence of circulating testosterone propionate (TP) and later after priming them with ovarian hormones (estradiol benzoate and progesterone; EB & P). When implanted with TP capsules and tested while sexually naive, all groups of female rats preferred females to males without differing statistically. However, following three sexual experience sessions with estrous females, differences emerged between the masculinized and control groups in the magnitude of their female-directed preference, with masculinized females demonstrating a significantly greater preference for estrous females. Sexual experience with male rats under EB & P did not result in a significant shift in preference in any group. Histological assessment indicated that the volume of the sexually dimorphic nucleus of the preoptic area (SDN-POA) was increased by exposure to TP postnatally, and SDN-POA volume correlated positively with partner preference scores but only when rats were both sexually experienced and exposed to circulating TP in adulthood. These results suggest that sexual experience interacts with steroid exposure to shape partner preference.
雄性和雌性大鼠视前区性二形核分化的激素敏感期的终止。
DOI：
10.1016/0165-3806(90)90217-m
发表时间：
1990
期刊：
Brain research. Developmental brain research
影响因子：
--
作者：
Rhees,RW;Shryne,JE;Gorski,RA
通讯作者：
Gorski,RA
学习辨别雄性日本鹌鹑（Coturnix coturnix japonica）同种性别：“生物约束”测试。
DOI：
10.1037//0097-7403.17.3.342
发表时间：
1991
期刊：
Journal of experimental psychology. Animal behavior processes
影响因子：
--
作者：
Nash,S;Domjan,M
通讯作者：
Domjan,M