Comparison of the Efficacy of Three Different Chlorhexidine Preparations in Decreasing the Levels of Mutans Streptococci in Saliva and Interdental Plaque
Comparison of the Efficacy of Three Different Chlorhexidine Preparations in Decreasing the Levels of Mutans Streptococci in Saliva and Interdental Plaque
复制标题
三种不同洗必泰制剂降低唾液和牙菌斑中变形链球菌水平的效果比较
DOI：
10.1159/000016440
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发表时间：
1998
期刊：
影响因子：
4.2
通讯作者：
L. Petersson
中科院分区：
文献类型：
--
作者：
S. Twetman;L. Petersson
本研究的目的是评估和比较三种不同的含氯己定 (CHX) 制剂对牙间菌斑和全唾液中变形链球菌 (MS) 水平的影响。通过筛查程序选择了 93 名唾液 MS 得分较高的健康学童（8-10 岁），并随机分为三个同等大小的组。借助于改进的椅旁技术，对第一恒磨牙所有近中牙间部位的 MS 进行了计数。然后，患者在 2 周内使用 1% CHX/百里酚清漆（A 组）或 1% CHX 凝胶（B 组）进行 3 次治疗，或者每天在监督下使用 0.4% CHX 牙膏刷牙，持续 1 个月（C 组）。治疗结束后1个月和3个月收集牙间部位的唾液和牙菌斑的后续样本。 1 个月后，所有组中唾液和牙间菌斑的 MS 水平均出现统计学显着降低。含 CHX 的牙膏（C 组）是降低唾液中 MS 水平的最有效方法，与凝胶和清漆形式相比，1 个月和 3 个月后发现明显更强的抑制作用（p < 0.05）。凝胶（B 组）往往比清漆（A 组）稍微更有效。在牙间菌斑中，MS 的减少不如唾液中的明显，三组的 MS 减少幅度相似（20%），持续时间也相似，可持续长达 3 个月。然而，所有齿间部位的很大一部分（约 50%）相对未受到治疗的影响。总之，我们的结果表明，无论 CHX 制备方法和方法如何，牙间 MS 定植都很难对抗，而唾液水平更容易受到影响。与使用凝胶或清漆相比，每天使用含 CHX 的牙膏刷牙可以更有效地减少唾液中的 MS。
The aim of the present study was to evaluate and compare the effects of three different chlorhexidine (CHX)-containing preparations on mutans streptococci (MS) levels in interdental plaque and whole saliva. Ninety-three healthy schoolchildren (8–10 years old) with high scores of salivary MS were selected by a screening procedure and randomised into three equally sized groups. MS were enumerated at all mesial interdental sites of the first permanent molars with aid of a modified chairside technique. The patients were then treated three times within 2 weeks with either a 1% CHX/thymol-containing varnish (group A) or a 1% CHX gel (group B), or they were subjected to daily supervised toothbrushing with a 0.4% CHX dentifrice for 1 month (group C). Follow-up samples of saliva and plaque from the interdental sites were collected 1 and 3 months after termination of treatment. A statistically significant reduction of MS levels in saliva and interdental plaque was found in all groups after 1 month. The CHX-containing dentifrice (group C) was the most effective method in reducing MS levels in saliva, and a significantly stronger (p < 0.05) suppression was found after 1 and 3 months when compared with the gel and the varnish forms. The gel (group B) tended to be slightly more effective than the varnish (group A). In the interdental plaque, the reduction of MS was less marked than in the saliva, and the three groups exhibited MS reductions of similar magnitude (20%) and duration, persisting up to 3 months. However, a high proportion (approximately 50%) of all interdental sites were relatively unaffected by the treatments. In conclusion, our results suggest that the interdental MS colonisation was difficult to combat, irrespective of CHX preparation and method, while the salivary levels were more easily affected. Daily tooth-brushing with a CHX-containing dentifrice was more effective in reducing MS in saliva compared with the gel or varnish applications.