Dietary patterns and blood levels of PCDDs, PCDFs, and dioxin-like PCBs in 1656 Japanese individuals
Dietary patterns and blood levels of PCDDs, PCDFs, and dioxin-like PCBs in 1656 Japanese individuals
复制标题
DOI：
10.1016/j.chemosphere.2010.11.008
复制
发表时间：
2011-01-01
期刊：
影响因子：
8.8
通讯作者：
Nagai, Masaki
中科院分区：
文献类型：
--
作者：
Arisawa, Kokichi;Uemura, Hirokazu;Nagai, Masaki
饮食模式与血液二恶英水平之间的关系尚未得到充分研究。目前的研究人群包括755名男性和901名女性（年龄15-73岁），居住在日本30个县的90个不同地区。通过询问28种食物、食物组和饮料的消费频率来评估饮食习惯。此外，29个多氯二苯并对二恶英（PCDDs），多氯二苯并呋喃（PCDFs），二恶英样多氯联苯（DL-PCBs）同系物的血液水平进行了高分辨率气相色谱/质谱测定。血液中的中位总毒性当量（TEQ）是根据世卫组织（2005年）的毒性当量因子计算的，为16 pg TEQ g（-1）脂质。主成分分析确定了五种饮食模式：健康饮食（高摄入量的蔬菜和水果）;肉类/高脂肪摄入量（高摄入量的肉类，肉制品和鸡蛋）;海鲜和酒精（高摄入量的鱼，贝类和酒精饮料）;杂项;和奶制品和酒精摄入量（高摄入量的牛奶，奶制品和酒精饮料）。调整性别，年龄，体重指数和吸烟习惯后，海鲜和酒精模式的分数显着相关的总TEQ和PCDDs/PCDFs/DL-PCBs的血液水平较高，和牛奶产品和酒精模式的分数与血液中的DL-PCBs水平较高。更详细的分析表明，酒精饮料和海鲜的摄入频率与总毒性当量以及多氯二苯并呋喃和DL-多氯联苯的毒性当量独立且呈正相关。酒精饮料摄入量和PCDDs之间的关联也很显着。分析饮食模式可能有助于确定二恶英身体负荷高的个人的饮食特征。(C)2010爱思唯尔有限公司版权所有。
The association between dietary patterns and blood dioxin levels has not been fully investigated. The present study population consisted of 755 men and 901 women (aged 15-73 years) living in 90 different areas of 30 prefectures of japan. Dietary habits were assessed by inquiring about the consumption frequency of 28 foods, food groups and beverages. In addition, the blood levels of 29 polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzo-furans (PCDFs), and dioxin-like polychlorinated biphenyl (DL-PCBs) congeners were determined by high-resolution gas chromatography/mass spectrometry. The median total toxicity equivalent (TEQ) in the blood, which was calculated on the basis of the toxicity equivalency factors of WHO (2005), was 16 pg TEQ g(-1) lipid. Principal component analysis identified five dietary patterns: Healthy diet (high intake of vegetables and fruits); Meat/High fat intake (high intake of meat, meat products, and eggs); Seafood and Alcohol (high intake of fish, shellfish, and alcoholic beverages); Miscellaneous; and Milk products and Alcohol intake (high intake of milk, Milk products, and alcoholic beverages). After adjusting for sex, age, body mass index, and smoking habits, the Seafood and Alcohol pattern scores were significantly related to higher blood levels of total TEQ and PCDDs/PCDFs/DL-PCBs, and the Milk products and Alcohol pattern scores were correlated with higher blood levels of DL-PCBs. More detailed analysis showed that the intake frequencies for alcoholic beverages and seafood were independently and positively associated with total TEQ and the TEQ of PCDFs and DL-PCBs. The association between alcoholic beverage intake and PCDDs was also significant. Analysis of dietary patterns may be useful for identifying the dietary characteristics of individuals with a high dioxin body burden. (C) 2010 Elsevier Ltd. All rights reserved.