Acidic peptides in brain: do they act at putative glutamatergic synapses?
Acidic peptides in brain: do they act at putative glutamatergic synapses?
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大脑中的酸性肽：它们是否作用于假定的谷氨酸突触？
DOI：
10.1007/978-1-4684-7971-3_28
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发表时间：
1986
影响因子：
--
通讯作者：
Carpenter,DO
中科院分区：
文献类型：
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作者：
Coyle,JT;Blakely,R;Zaczek,R;Koller,KJ;Abreu,M;Ory-Lavollée,L;Fisher,R;ffrench-Mullen,JM;Carpenter,DO
谷氨酸(GLU)和/或天冬氨酸(ASP)被认为是哺乳动物大脑中最有可能的兴奋性神经递质(Curtis和Johnston，1974；Cotman等，1981；Watkins和Evans，1981；Fonnum，1984)。然而，对这一推论仍有一定的保留意见，因为这些氨基酸参与了几种代谢途径，包括蛋白质合成，而且它们对脑神经元表现出相当一致的兴奋作用。此外，关于离子电泳法应用GLU/ASP的药理学与推测的GLU/ASP突触释放的内源性兴奋性神经递质之间的药理不一致的报道已经出现。例如，Hori等人。(1981)证明了α-氨基膦酸丁酸(APB)拮抗由外侧嗅束(LOT)释放的兴奋性神经递质的作用，但不对抗离子导入应用的GLU和ASP的兴奋效应，这两种神经递质已被认为是Lot的神经递质，基于它们的选择性摄取和诱发释放(Bradford and Richards，1976；Collins，1978)。Shiells等人。(1981)观察到GLU对视网膜双极细胞的神经生理学作用不同于由光感受器释放的内源性神经递质，被称为GLU。
Glutamic acid (GLU) and/or aspartic acid (ASP) are considered the most likely candidates as the predominant excitatory neurotransmitters in the mammalian brain (Curtis and Johnston, 1974; Cotman et al., 1981; Watkins and Evans, 1981; Fonnum, 1984). Nevertheless, certain reservations about this inference remain because these amino acids are involved in several metabolic pathways, including protein synthesis, and because they exhibit rather uniform excitatory effects on brain neurons. Furthermore, reports of inconsistencies between the pharmacology of ionophoretically applied GLU/ASP and that of the endogenous excitatory neurotransmitter released at putative GLU/ASP synapses have appeared. For example, Hori et al. (1981) demonstrated that a-amino-phosphono-butyric acid (APB) antagonized the effects of the excitatory neurotransmitter released by the lateral olfactory tract (LOT) but not the excitatory effects of ionophoretically applied GLU and ASP, which have been proposed as neurotransmitters for the LOT based upon their selective uptake and evoked release (Bradford and Richards, 1976; Collins, 1978). Shiells et al. (1981) have observed differences in the neurophysiologie effects of GLU on retinal bipolar cells from that of the endogenous neurotransmitter released by the photoreceptors, which is reputed to be GLU.