Metabolism of designer drugs of abuse: an updated review.
Metabolism of designer drugs of abuse: an updated review.
复制标题
滥用设计药物的代谢：最新综述。
作者：
M. Meyer;H. Maurer
本文回顾了过去几年中出现在黑市上的新设计药物的代谢，是2005年发表的一篇综述的更新。所提出的审查包含有关所谓的2C化合物的数据4-溴-2，5-二甲氧基-β-苯乙胺（2C-B）、4-碘-2，5-二甲氧基-β-苯乙胺（2C-I）、2，5-二甲氧基-4-甲基-β-苯乙胺（2C-D）、4-乙基-2，5-二甲氧基-β-苯乙胺（2C-E）、4-乙硫基-2，5-二甲氧基-β-苯乙胺（2C-T-2）、和2，5-二甲氧基-4-丙硫基-β-苯乙胺（2C-T-7），β-酮设计药物如2-甲氨基-1-（3，4-亚甲二氧基苯基）丁酮（丁酮，bk-MBDB），2-乙基氨基-1-（3，4-亚甲二氧基苯基）丙酮（乙酮，bk-MDEA），2-甲氨基-1-（3，4-亚甲基并二氧基并苯基）丙-1-酮（甲酮，bk-MDMA）和2-甲氨基-1-对甲苯基丙烷-1-酮（甲氧麻黄酮，4-甲基-甲卡西酮），吡咯烷酮，如4-甲基-吡咯烷酮（MPBP）和α-吡咯烷酮戊酮（PVP），苯环己哌啶衍生药物，如N（1苯基环己基）丙胺（PCPr），N-（1-苯基环己基）-2-乙氧基乙胺（PCEEA），N-（1-苯基环己基）-3-甲氧基丙胺（PCMPA），和（1-苯基环己基）-2-甲氧基乙胺（PCMEA），色胺如5-甲氧基-N，N-二异丙基色胺（5-MeO-DIPT），最后是α-甲基芬太尼（α-MF）和3-甲基芬太尼（3-MF）。已考虑并审查了关于体内或体外人或动物代谢物和细胞色素P450或单胺氧化酶同工酶依赖性代谢的鉴定的论文。
This paper reviews the metabolism of new designer drugs of abuse that have emerged on the black market during the last years and is an update of a review published in 2005. The presented review contains data concerning the so-called 2C compounds (phenethylamine type) such as 4-bromo-2,5-dimethoxy-beta-phenethylamine (2C-B), 4-iodo-2,5-dimethoxy-beta-phenethylamine (2C-I), 2,5-dimethoxy-4-methyl-beta-phenethylamine (2C-D), 4-ethyl-2,5-dimethoxy-beta-phenethylamine (2C-E), 4-ethylthio-2,5-dimethoxy-beta-phenethylamine (2C-T-2), and 2,5-dimethoxy-4-propylthio-beta-phenethylamine (2C-T-7), beta-keto designer drugs such as 2-methylamino-1-(3,4-methylenedioxyphenyl)butan-1-one (butylone, bk-MBDB), 2-ethylamino-1-(3,4-methylenedioxyphenyl)propan-1-one (ethylone, bk-MDEA), 2-methylamino-1-(3,4-methylene notdioxy notphenyl)propan-1-one (methylone, bk-MDMA), and 2-methylamino-1-p-tolylpropane-1-one (mephedrone, 4-methyl-methcathinone), pyrrolidino notphenones such as 4-methyl-pyrrolidinobutyrophenone (MPBP) and alpha-pyrrolidinovalerophenone (PVP), phencyclidine-derived drugs such as N (1 phenylcyclohexyl) propanamine (PCPr), N-(1-phenylcyclohexyl)-2-ethoxyethanamine (PCEEA), N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA), and N-(1-phenylcyclohexyl)-2-methoxyethanamine (PCMEA), tryptamines such as 5-methoxy-N,N-diisopropyl nottryptamine (5-MeO-DIPT), and finally alpha-methylfentanyl (alpha-MF) and 3-methylfentanyl (3-MF). Papers have been considered and reviewed on the identification of in vivo or in vitro human or animal metabolites and the cytochrome P450 or monoamineoxidase isoenzyme-dependent metabolism.
影响因子：
7.3
作者：
Meltzer, PC;Butler, D;Madras, BK
通讯作者：
Madras, BK
影响因子：
5.8
作者：
Narimatsu, S;Yonemoto, R;Hanioka, N
通讯作者：
Hanioka, N