Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice
Heme Induces IL-6 and Cardiac Hypertrophy Genes Transcripts in Sickle Cell Mice
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DOI：
10.3389/fimmu.2020.01910
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发表时间：
2020-08-21
影响因子：
7.3
通讯作者：
Kato, Gregory J.
中科院分区：
文献类型：
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作者：
Gbotosho, Oluwabukola T.;Kapetanaki, Maria G.;Kato, Gregory J.
新数据表明，游离血红素会促进许多不同疾病的炎症，包括镰状细胞病 (SCD)。尽管游离血红素、促炎细胞因子和心脏肥大是 SCD 的共存特征，但尚未证明这些特征之间存在机制联系。我们现在报告，汤斯镰状细胞病 (SS) 小鼠心脏中 IL-6 mRNA 和蛋白质的水平显着升高（2.9 倍，p
Emerging data indicate that free heme promotes inflammation in many different disease settings, including in sickle cell disease (SCD). Although free heme, proinflammatory cytokines, and cardiac hypertrophy are co-existing features of SCD, no mechanistic links between these features have been demonstrated. We now report significantly higher levels of IL-6 mRNA and protein in hearts of the Townes sickle cell disease (SS) mice (2.9-fold,p