Total Synthesis of Chivosazole F
Total Synthesis of Chivosazole F
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DOI：
10.1021/ja107290s
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发表时间：
2010-10-06
影响因子：
15
通讯作者：
Kalesse, Markus
中科院分区：
文献类型：
--
作者：
Brodmann, Tobias;Janssen, Dominic;Kalesse, Markus
首次合成了具有高生物活性的奇沃沙唑F。它的特点是大环内酯形成的分子内Stille偶联，从而避免了与四烯片段相关的异构化问题。此外，该合成证实了仅基于NMR/计算方法和遗传分析的组合提出的结构。
The first synthesis of the highly biologically active chivosazole F is described. It features an intramolecular Stille coupling for the macrolactone formation and thereby circumvents the problem of isomerization associated with the tetraene segment. Additionally, the synthesis confirms the structure which has been proposed based solely on a combination of NMR/computational methods and genetic analysis.