Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta.
Bioanalytical and instrumental analysis of estrogenic activities in drinking water sources from Yangtze River Delta.
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DOI：
10.1016/j.chemosphere.2012.10.095
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发表时间：
2013-02
期刊：
影响因子：
8.8
通讯作者：
Xinxin Hu;W. Shi;Fu Cao;Guan-jiu Hu;Yingqun Hao;Si Wei;Xinru Wang;Hongxia Yu
中科院分区：
文献类型：
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作者：
Xinxin Hu;W. Shi;Fu Cao;Guan-jiu Hu;Yingqun Hao;Si Wei;Xinru Wang;Hongxia Yu
以非洲绿猴肾(CV-1)细胞系为研究对象，采用报告基因分析方法，测定了长江、淮河、太湖水源水和长江三角洲地下水在枯水期和丰水期的雌激素样活性。枯水期具有较高的雌激素活性，太湖水样的雌激素潜能大于其他流域。地下水样品均未显示雌激素受体(ER)激动剂活性。枯水期17个雌二醇(β-Estradiol，E_2)当量(EEQs)为9.41×10~(-1)−~(-1)~1.2×10~(-1)ngE_2L~(-1)−~1。丰水期除淮河水样外，其余水样EEQ均低于检出限9×10~(−)~(NgE_2L)−~1。在长江中，雌激素的贡献率最高，占雌激素活性的99%。水源地中的雌激素活性可能还与壬基酚(NP，100%检出)和辛基酚(OP，100%)有关。饮用水源水中的雌激素化合物可能会对居民构成潜在的健康风险。
The estrogenic activities of source water from Yangtze River, Huaihe River, Taihu Lake and groundwater in Yangtze River Delta in the dry and wet season were determined by use of reporter gene assays based on African green monkey kidney (CV-1) cell lines. Higher estrogenic activities were observed in the dry season, and the estrogenic potentials in water samples from Taihu Lake were greater than other river basins. None of the samples from groundwater showed estrogen receptor (ER) agonist activity. The 17β-Estradiol (E2) equivalents (EEQs) of water samples in the dry season ranged from 9.41×10−1to 1.20×101ngE2L−1. In the wet season, EEQs of all the water samples were below the detection limit as 9.00×10−1ngE2L−1except for one sample from Huaihe River. The highest contribution of E2 was detected in Yangtze River as 99% of estrogenic activity. Nonylphenol (NP, 100% detection rate) and octylphenol (OP, 100% detection rate) might also be responsible for the estrogenic activities in water sources. Potential health risk induced by the estrogenic chemicals in source water may be posed to the residents through water drinking.