INTERLEUKIN-2 - INCEPTION, IMPACT, AND IMPLICATIONS
INTERLEUKIN-2 - INCEPTION, IMPACT, AND IMPLICATIONS
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DOI：
10.1126/science.3131876
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发表时间：
1988-05-27
期刊：
影响因子：
56.9
通讯作者：
SMITH, KA
中科院分区：
文献类型：
--
作者：
SMITH, KA
白细胞介素-2（IL-2）是第一个被识别和完全鉴定的一系列淋巴细胞激素，在免疫应答的产生和调节中起着关键作用。作为淋巴细胞产物，IL-2也通过与其特异性膜受体的有限数量的相互作用刺激T细胞经历细胞周期进程。由于抗原攻击后的T细胞克隆增殖对于免疫应答和免疫记忆是必须的，因此IL-2-T细胞系统为对生物学、免疫学和医学基础现象的分子理解开辟了道路。
Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and completely characterized, is pivotal for the generation and regulation of the immune response. A lymphocyte product, IL-2 also stimulates T cells to undergo cell cycle progression via a finite number of interactions with its specific membrane receptors. Because T cell clonal proliferation after antigen challenge is obligatory for immune responsiveness and immune memory, the IL-2-T cell system has opened the way to a molecular understanding of phenomena that are fundamental to biology, immunology, and medicine.