Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden
Estimated frequency of genetic and nongenetic causes of congenital idiopathic cerebral palsy in west Sweden
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DOI：
10.1046/j.1529-8817.2004.00105.x
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发表时间：
2004-09-01
影响因子：
1.9
通讯作者：
Costeff, H
中科院分区：
文献类型：
--
作者：
Costeff, H
在瑞典西部人群为基础的脑瘫（CP）研究中，对第一批681例特发性先天性脑瘫（出生于1959-1970年）病例进行了产前和围产期危险因素的数学分析。分析表明，社区中估计有40%的病因学未确诊的CP病例（48%的足月出生病例和24%的早产病例）是遗传引起的。遗传因素在CP中所占的比例并不比在特发性精神发育迟滞中少。遗传原因占60%的先天性偏瘫，45%的先天性痉挛性双瘫，32%的早产儿痉挛性双瘫和几乎所有的纯粹共济失调病例。根据两阶段模型，社区中约23%的CP病例患有非遗传性脑损伤。37%的残留物的特征在于单一的风险因素，通常是围产期的。
Mathematical analysis of prenatal and perinatal risk factors was performed on the first 681 published cases of idiopathic congenital cerebral palsy (born 1959-1970) in the west Swedish population-based cerebral palsy (CP) study. Analysis indicates that an estimated 40% of etiologically undiagnosed cases of CP in the community (48% of those born at term and 24% of those born prematurely) are genetically caused. These proportions of genetic causation are no less in CP than in idiopathic mental retardation. Genetic causes account for 60% of maturely born hemiplegics, 45% of maturely born spastic diplegics, 32% of premature spastic diplegics and virtually all cases of pure ataxia. About 23% of CP cases in the community have suffered nongenetic brain damage in accordance with the two-stage model. The residue of 37% is characterized by a single risk factor, usually perinatal.