Prenatal undernutrition and cognitive function in late adulthood
Prenatal undernutrition and cognitive function in late adulthood
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DOI：
10.1073/pnas.1009459107
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发表时间：
2010-09-28
影响因子：
11.1
通讯作者：
Roseboom, Tessa J.
中科院分区：
文献类型：
--
作者：
de Rooij, Susanne R.;Wouters, Hans;Roseboom, Tessa J.
第二次世界大战结束时，荷兰西部的城市发生了为期5个月的严重饥荒。在最高峰时，配给量下降到每天400卡路里。1972年，据报道，19岁男性应征入伍者的认知能力没有受到出生前饥荒的影响。在目前的研究中，我们发现，在以后的生活中，认知功能似乎确实受到产前营养不良的影响。我们发现，在56岁至59岁之间，在妊娠早期遭受饥荒的男性和女性在选择性注意任务中的表现较差，这种认知能力通常会随着年龄的增长而下降。我们假设这种下降可能是认知老化过程加速的早期表现。
the end of World War II, a severe 5-mo famine struck the cities in the western part of The Netherlands. At its peak, the rations dropped to as low as 400 calories per day. In 1972, cognitive performance in 19-y-old male conscripts was reported not to have been affected by exposure to the famine before birth. In the present study, we show that cognitive function in later life does seem affected by prenatal undernutrition. We found that at age 56 to 59, men and women exposed to famine during the early stage of gestation performed worse on a selective attention task, a cognitive ability that usually declines with increasing age. We hypothesize that this decline may be an early manifestation of an accelerated cognitive aging process.