Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
Relation between retinol, retinol-binding protein 4, transthyretin and carotid intima media thickness
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DOI：
10.1016/j.atherosclerosis.2010.07.063
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发表时间：
2010-12-01
期刊：
影响因子：
5.3
通讯作者：
Spranger, Joachim
中科院分区：
文献类型：
--
作者：
Bobbert, Thomas;Raila, Jens;Spranger, Joachim
目的：视黄醇在循环中与视黄醇结合蛋白 4 (RBP4) 和运甲状腺素蛋白 (TTR) 形成复合物进行运输。虽然视黄醇与各种心血管危险因素相关，但视黄醇、RBP4、TTR 和颈动脉内膜中层厚度 (IMT) 之间的关系尚未分析。方法：在 96 名个体中测量视黄醇、RBP4 和 TTR，并确定它们与平均和最大 IMT 的关系。结果：平均 IMT 与 RBP4（r = 0.335，p < 0.001）、视黄醇（r = -0.241，p = 0.043），RBP/TTR 比率（r = 0.254，p = 0.025）和视黄醇/RBP4 比率（r = -0.549，p < 0.001）。对年龄、性别、BMI、血压、HDL/总胆固醇比率、甘油三酯、糖尿病和吸烟进行调整后发现，视黄醇/RBP4比率与平均IMT密切且独立相关。对于最大 IMT（包括斑块的测量）也发现了类似的结果。结论：数据支持维生素 A 的转运复合物与 IMT（动脉粥样硬化的既定参数）相关。视黄醇 RBP4 饱和度的变化可能将肾功能障碍和胰岛素抵抗与动脉粥样硬化联系起来。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Objective: Retinol is transported in a complex with retinol-binding protein 4 (RBP4) and transthyretin (TTR) in the circulation. While retinol is associated with various cardiovascular risk factors, the relation between retinol, RBP4, TTR and carotid intima media thickness (IMT) has not been analysed yet.Methods: Retinol, RBP4 and TTR were measured in 96 individuals and their relation to mean and maximal IMT was determined.Results: Mean IMT correlated with RBP4 (r = 0.335, p < 0.001), retinol (r = -0.241, p = 0.043), RBP/TTR ratio (r = 0.254, p = 0.025) and retinol/RBP4 ratio (r = -0.549, p < 0.001). Adjustment for age, sex, BMI, blood pressure, HDL/total cholesterol ratio, triglyceride, diabetes and smoking revealed that the retinol/RBP4 ratio was strongly and independently associated with mean IMT. Similar results were found for maximal IMT, which included the measurement of plaques.Conclusion: The data support that the transport complex of vitamin A is associated with the IMT, an established parameter of atherosclerosis. Changes in RBP4 saturation with retinol may link renal dysfunction and insulin resistance to atherosclerosis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.