A PLASMODIUM-FALCIPARUM ANTIGEN THAT BINDS TO HOST ERYTHROCYTES AND MEROZOITES
A PLASMODIUM-FALCIPARUM ANTIGEN THAT BINDS TO HOST ERYTHROCYTES AND MEROZOITES
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DOI：
10.1126/science.3901257
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发表时间：
1985-01-01
期刊：
影响因子：
56.9
通讯作者：
CAMUS, D
中科院分区：
文献类型：
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作者：
CAMUS, D
在一种培养的人类疟疾寄生虫(恶性疟原虫)的上清液中发现了与红细胞结合的抗原。一种175K(175K)的抗原，只与易受入侵的红细胞结合。来自Camp或FCR-3株的175K抗原也与裂殖子结合。然而，当裂殖子和上清抗原来自不同的菌株时，该抗原不能与裂殖子结合，除非有蛋白酶抑制剂存在。此外，包被Camp或FCR-3菌株上清液抗原的红细胞可被同源菌株的裂殖子正常入侵，但对异源菌株的裂殖子入侵有部分抵抗力。175K抗原可能是一种受体，在红细胞和裂殖子之间起着桥梁作用。
Antigens that bind to erythrocytes were identified in the supernatant fluids of a cultured human malaria parasite (Plasmodium falciparum). A 175-kilodalton (175K) antigen bound only to erythrocytes susceptible to invasion. The 175K antigen from the Camp or the FCR-3 strain also bound to merozoites. However, the antigen did not bind to merozoites when merozoites and supernatant antigens were from different strains unless proteinase inhibitors were present. Moreover, erythrocytes coated with supernatant antigens from the Camp or FCR-3 strain were invaded normally by merozoites of the homologous strain but were partially resistant to invasion by merozoites of the heterologous strain. The 175K antigen may be a receptor acting as a "bridge" between erythrocytes and merozoites.