Abnormalities of cortical thickness in postictal psychosis
Abnormalities of cortical thickness in postictal psychosis
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DOI：
10.1016/j.yebeh.2011.03.024
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发表时间：
2011-06-01
影响因子：
2.6
通讯作者：
Thesen, T.
中科院分区：
文献类型：
--
作者：
DuBois, J. M.;Devinsky, O.;Thesen, T.
后发精神病（PIP）是癫痫发作后精神病发作的发生，是癫痫患者常见且严重的合并症。然而，解剖学上的相关性仍然不明确。在这里，我们使用定量MRI形态测定法来识别PIP患者相对于无PIP的癫痫患者和年龄和性别匹配的正常健康对照者的皮质结构异常。癫痫合并PIP患者与未合并PIP的癫痫患者相比，右侧外侧前额叶皮层、右侧前扣带皮层和右侧颞中回皮质厚度增加。PIP组与EC和NC组的区别在于右侧扣带前吻侧皮层较厚，右侧角回和左侧颞中区皮层较薄。研究结果表明，PIP与右侧前扣带皮层增厚有关，这可能是患PIP风险患者的标志。Elsevier Inc.出版。
Postictal psychosis (PIP), the occurrence of psychotic episodes following a seizure, is a common and serious comorbidity in patients with epilepsy. Yet, the anatomical correlates remain poorly defined. Here, we used quantitative MRI morphometry to identify structural abnormalities in the cortex of patients with PIP relative to patients with epilepsy without PIP and age- and gender-matched normal healthy controls. Comparison of patients with epilepsy and PIP with patients with epilepsy without PIP revealed increased cortical thickness in the right lateral prefrontal cortex, right anterior cingulate cortex, and right middle temporal gyrus. The PIP group was distinguished from the EC and NC groups by thicker cortex in the right rostral anterior cingulate cortex and thinner cortex in the right angular gyrus and the left middle temporal region. Findings indicate that PIP is associated with thickening of the right anterior cingulate cortex, which may serve as a marker for patients at risk for developing PIP. Published by Elsevier Inc.