Epidemiology of rotavirus diarrhea in a prospectively monitored American Indian population.
Epidemiology of rotavirus diarrhea in a prospectively monitored American Indian population.
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前瞻性监测的美洲印第安人群体中轮状病毒腹泻的流行病学。
DOI：
10.1093/infdis/152.4.778
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Sack,RB
中科院分区：
文献类型：
--
作者：
Santosham,M;Yolken,RH;Wyatt,RG;Bertrando,R;Black,RE;Spira,WM;Sack,RB
轮状病毒腹泻在世界大多数地区流行，但在前瞻性监测人群中尚未报告社区范围的流行。这项腹泻病因的前瞻性研究从1981年4月开始，每两周访问10070名白山阿帕奇印第安人的家庭。在1981年10月21日开始的三个星期期间，在保留区的不同地区发现了342例新的腹泻病例。经酶联免疫吸附试验检测的轮状病毒抗原在检测的233份粪便样本中的169份（73%）中被鉴定出来。在疫情前后6个月采集的粪便样本中未检出轮状病毒。疫情期间，135例轮状病毒阳性患者中有44例（33%）出现呼吸道症状，98例轮状病毒阴性患者中有17例（17%）出现呼吸道症状（P< 0.05）。在没有病人共同接触源的情况下，这种流行病在保留地所有地区迅速蔓延，表明有可能通过呼吸道传播。
Rotaviral diarrhea is endemic in most areas of the world, yet community-wide epidemics have not been reported in prospectively monitored populations. This prospective study of the etiology of diarrhea included biweekly visits to the homes of 10070 of the population of the White Mountain Apache Indians and began in April 1981. During a three-week period beginning 21 October, 1981, 342 new cases of diarrhea were identified on different parts of the reservation. Rotaviral antigen, detected by an enzyme-linked immunosorbent assay, was identified in 169 (73%) of the 233 stool samples that were tested. Rotavirus was not detected in any of the stool samples taken six months before or after the epidemic. During the epidemic, respiratory symptoms were present in 44 (33%) of 135 rotavirus-positive patients compared with 17 (17%) of 98 rotavirus-negative patients (P< .05). This rapidly spreading epidemic involving all areas of the reservation, in the absence of a common source of exposure of ill persons, suggests the possibility of respiratory transmission.