Life Course Air Pollution Exposure and Cognitive Decline: Modelled Historical Air Pollution Data and the Lothian Birth Cohort 1936.
Life Course Air Pollution Exposure and Cognitive Decline: Modelled Historical Air Pollution Data and the Lothian Birth Cohort 1936.
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DOI：
10.3233/jad-200910
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Pearce JR
中科院分区：
文献类型：
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作者：
Russ TC;Cherrie MPC;Dibben C;Tomlinson S;Reis S;Dragosits U;Vieno M;Beck R;Carnell E;Shortt NK;Muniz-Terrera G;Redmond P;Taylor AM;Clemens T;van Tongeren M;Agius RM;Starr JM;Deary IJ;Pearce JR
空气污染一直被认为与痴呆症和认知能力下降有关。然而，目前尚不清楚风险是通过长期敞口积累的，还是存在敏感/关键时期。澄清这种关系的一个关键障碍是缺乏历史空气污染数据。论证模拟历史空气污染数据并将其用于流行病学模型的可行性。使用EMEP4UK大气化学传输模型，我们模拟了1935年、1950年、1970年、1980年和1990年的历史细颗粒物(PM2.5)浓度，并将这些浓度与2001年的当代建模数据结合起来，估计了1936年洛锡安出生队列中572名参与者的一生暴露，并记录了终身居住史。用Moray House测验测量的11、70、76、79岁儿童的认知能力(IQ)构建线性回归和潜在生长模型，以探讨历史空气污染暴露的影响。协变量包括性别、11岁时的智商、社会阶层和吸烟。以1935年为模型的较高空气污染(当时参与者应该在子宫中)与11-70岁(β = -0.006，SE = 0.002，p = 0.03)的智商变化更严重相关，但与70-79岁的认知轨迹无关(p >； 0.05)。没有支持其他关键/敏感期的暴露或风险积累(所有p >； 均为0.05)。生命过程范式是理解认知衰退的关键，这是第一次研究生命过程中暴露于空气污染与认知健康的关系。
Air pollution has been consistently linked with dementia and cognitive decline. However, it is unclear whether risk is accumulated through long-term exposure or whether there are sensitive/critical periods. A key barrier to clarifying this relationship is the dearth of historical air pollution data. To demonstrate the feasibility of modelling historical air pollution data and using them in epidemiologicalmodels. Using the EMEP4UK atmospheric chemistry transport model, we modelled historical fine particulate matter (PM2.5) concentrations for the years 1935, 1950, 1970, 1980, and 1990 and combined these with contemporary modelled data from 2001 to estimate life course exposure in 572 participants in the Lothian Birth Cohort 1936 with lifetime residential history recorded. Linear regression and latent growth models were constructed using cognitive ability (IQ) measured by the Moray House Test at the ages of 11, 70, 76, and 79 years to explore the effects of historical air pollution exposure. Covariates included sex, IQ at age 11 years, social class, and smoking. Higher air pollution modelled for 1935 (when participants would have been in utero) was associated with worse change in IQ from age 11–70 years (β = –0.006, SE = 0.002, p = 0.03) but not cognitive trajectories from age 70–79 years (p > 0.05). There was no support for other critical/sensitive periods of exposure or an accumulation of risk (all p > 0.05). The life course paradigm is essential in understanding cognitive decline and this is the first study to examine life course air pollution exposure in relation to cognitive health.