Site-directed delivery of ferritin-encapsulated gold nanoparticles
Site-directed delivery of ferritin-encapsulated gold nanoparticles
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DOI：
10.1088/0957-4484/21/4/045305
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发表时间：
2010-01
期刊：
影响因子：
3.5
通讯作者：
B. Zheng;I. Yamashita;M. Uenuma;K. Iwahori;M. Kobayashi;Y. Uraoka
中科院分区：
文献类型：
--
作者：
B. Zheng;I. Yamashita;M. Uenuma;K. Iwahori;M. Kobayashi;Y. Uraoka
报道了新设计的转运蛋白，其捕获金纳米颗粒并在特定条件下将纳米颗粒选择性地递送到二氧化硅（SiO2）表面。重组脱铁铁蛋白亚基，其中每一个具有金结合肽和钛结合肽在C-和N-末端，分别，可以有效地封装金纳米颗粒。生物缀合物，纳米金和周围的突变蛋白质亚基，具有可以通过相互作用将自身递送到SiO2表面的性质。从理论上讲，我们的基因操纵的脱铁铁蛋白亚基可以封装各种大小的金纳米粒子，这是一个有前途的性质，涉及表面等离子体共振的应用。
Newly designed porter proteins, which catch gold nanoparticles and deliver the nanoparticles selectively to a silicon dioxide (SiO2) surface under the specific conditions were reported. Recombinant apoferritin subunits, each of which has gold-binding peptide and titanium-binding peptide at the C- and N-terminus, respectively, can efficiently encapsulate a gold nanoparticle. The bio-conjugate, a nanogold and surrounding mutant protein subunits, had a property which can deliver itself to the SiO2 surface through the interaction. In theory, our genetically manipulated apoferritin subunits can encapsulate gold nanoparticles of various sizes, which is a promising property for applications involving surface plasmon resonance.