Population structure and transmission dynamics of plasmodium vivax in rural amazonia
Population structure and transmission dynamics of plasmodium vivax in rural amazonia
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DOI：
10.1086/512685
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发表时间：
2007-04-15
影响因子：
6.4
通讯作者：
Hartl, Daniel L.
中科院分区：
文献类型：
--
作者：
Ferreira, Marcelo U.;Karunaweera, Nadira D.;Hartl, Daniel L.
了解疟疾寄生虫的遗传结构对于预测某些感兴趣的表型在人群中起源和传播的速度是至关重要的。在本研究中，我们使用高度多态的微卫星标记对在巴西亚马逊地区疟疾低流行地区收集的74株间日疟原虫分离株进行了横断面和纵向调查，并探讨了遗传多样性的单倍型或菌株的传播动力学。间日疟原虫种群的多样性和多克隆感染的频率高于共地恶性疟原虫分离株，但这些特征与高水平的近亲交配共存，导致显著的多位点连锁不平衡。此外，我们在15个月的跟踪调查中发现的微卫星单倍型更替的高比率很可能不是由于强大的多样化选择造成的。我们的结论是，低水平传播下间日疟原虫种群的小区域遗传多样性并没有受到有效减数分裂重组率低的严重制约，具有明显的公共卫生影响。
Understanding the genetic structure of malaria parasites is essential to predict how fast some phenotypes of interest originate and spread in populations. In the present study, we used highly polymorphic microsatellite markers to analyze 74 Plasmodium vivax isolates, which we collected in cross-sectional and longitudinal surveys performed in an area of low malaria endemicity in Brazilian Amazonia, and to explore the transmission dynamics of genetically diverse haplotypes or strains. P. vivax populations are more diverse and more frequently comprise multiple-clone infections than do sympatric Plasmodium falciparum isolates, but these features paradoxically coexist with high levels of inbreeding, leading to significant multilocus linkage disequilibrium. Moreover, the high rates of microsatellite haplotype replacement that we found during 15 months of follow-up most likely do not result from strong diversifying selection. We conclude that the small-area genetic diversity in P. vivax populations under low-level transmission is not severely constrained by the low rates of effective meiotic recombination, with clear public health implications.