Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
Phonetic mismatch negativity predicts verbal memory deficits in schizophrenia
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DOI：
10.1097/01.wnr.0000221828.10846.ba
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发表时间：
2006-07-17
期刊：
影响因子：
1.7
通讯作者：
Kato, Nobumasa
中科院分区：
文献类型：
--
作者：
Kawakubo, Yuki;Kasai, Kiyoto;Kato, Nobumasa
以错配负性为指标的电生理水平的听觉记忆缺陷和神经心理水平的听觉言语记忆缺陷已在以往的精神分裂症研究中得到独立证实。我们预测这些指标在精神分裂症中有特定的关联。对23例精神分裂症患者进行了声调持续时间和音素持续时间变化引起的失配负性反应，并对其进行了听觉言语记忆和执行功能评估。在音素持续时间条件下，错配负性振幅越低，言语记忆越差。音素-时间错配负性与执行功能无关，语调-时间错配负性与言语记忆无关。这些结果表明，电生理听觉感觉记忆功能障碍是精神分裂症患者神经心理听觉言语记忆缺陷的基础。
Deficits in auditory sensory memory at the electrophysiological level as indexed by mismatch negativity and those in auditory verbal memory at the neuropsychological level have been independently demonstrated in previous studies of schizophrenia. We predicted a specific association between these indices in schizophrenia. Mismatch negativities elicited by change in tone duration and phoneme duration were recorded in 23 schizophrenia patients, who were also evaluated for auditory verbal memory and executive function. Lower amplitude of mismatch negativity under the phoneme-duration condition was significantly associated with worse verbal memory. Phoneme-duration mismatch negativity was not correlated with executive function, nor was tone-duration mismatch negativity correlated with verbal memory. These results suggest that electrophysiological auditory sensory memory dysfunction underlies the basis for neuropsychological auditory verbal memory deficits in schizophrenia.