Alcohol consumption increases the risk of fatal breast cancer (United States)
Alcohol consumption increases the risk of fatal breast cancer (United States)
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DOI：
10.1023/a:1013737616987
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发表时间：
2001-12-01
影响因子：
2.3
通讯作者：
Thun, MJ
中科院分区：
文献类型：
--
作者：
Feigelson, HS;Calle, EE;Thun, MJ
目的：探讨饮酒增加乳腺癌死亡风险的假说。方法：我们检查了美国癌症协会癌症预防研究(CPS)-II中女性自我报告的饮酒与乳腺癌死亡率的关系。后14。在多年的随访中，在242,010名妇女中观察到1,442名符合条件的乳腺癌死亡。分别为总饮酒量和啤酒、葡萄酒和白酒构建了Cox比例风险模型。结果：在绝经前或围绝经期妇女中，总饮酒量与致命性乳腺癌风险增加有关。与不饮酒者相比，即使每天喝不到一杯，绝经后妇女的乳腺癌死亡率也会增加30% （RR = 1.3, 95% CL = 1.1-1.6）
Objective: To investigate the hypothesis that alcohol consumption increases the risk of breast cancer mortality.Methods: We examined breast cancer mortality in relation to self-reported alcohol consumption in women from the American Cancer Society Cancer Prevention Study (CPS)-II. After 14. years of follow-up, 1,442 eligible breast cancer deaths were observed among 242,010 women. Cox proportional hazards models were constructed for total alcohol consumption and for beer, wine, and liquor separately.Results: Total alcohol consumption was associated with increased risk of fatal breast cancer among post- but not pre- or perimenopausal women. Even less than one drink/day was associated with up to a 30% increase in breast cancer mortality among postmenopausal women compared to non-drinkers (RR = 1.3, 95% CL 1.1-1.6 for women drinking 0.26-