Sulfenate Esters of Simple Phenols Exhibit Enhanced Activity against Biofilms.
Sulfenate Esters of Simple Phenols Exhibit Enhanced Activity against Biofilms.
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简单酚的磺酸酯表现出增强的抗生物膜活性。
DOI：
10.1021/acsomega.9b04392
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发表时间：
2020
期刊：
影响因子：
4.1
通讯作者：
Stewart,PhilipS
中科院分区：
文献类型：
--
作者：
Walsh,DanicaJ;Livinghouse,Tom;Durling,GregM;Chase-Bayless,Yenny;Arnold,AdrienneD;Stewart,PhilipS
微生物生物膜对传统消毒剂表现出的顽固性促使了控制和根除生物膜的新化学策略的发展。研究了几种小分子酚类化合物及其三氯甲基亚硫酯衍生物对浮游细胞和成熟生物膜表皮葡萄球菌和铜绿假单胞菌的抑制作用。一些酚类母体化合物是植物精油中研究得很好的成分，例如丁香酚、薄荷醇、香芹酚和百里香酚。磺酸酯类化合物对浮游细胞和生物膜的效力显著并持续增加。母体和衍生物对浮游细胞的最低抑菌浓度之间的平均倍数差为44fors。表皮病变16例，P。铜绿假单胞菌。22个受试化合物的母体和衍生生物膜根除浓度之间的平均倍数差异。表皮病和P。铜绿假单胞菌3。这项工作证明了一种新型的以生物膜为靶标的消毒剂部署磺酸酯官能团的可能性，以增加对生物膜中微生物的抗菌效力。
The recalcitrance exhibited by microbial biofilms to conventional disinfectants has motivated the development of new chemical strategies to control and eradicate biofilms. The activities of several small phenolic compounds and their trichloromethylsulfenyl ester derivatives were evaluated against planktonic cells and mature biofilms ofStaphylococcus epidermidisandPseudomonas aeruginosa. Some of the phenolic parent compounds are well-studied constituents of plant essential oils, for example, eugenol, menthol, carvacrol, and thymol. The potency of sulfenate ester derivatives was markedly and consistently increased toward both planktonic cells and biofilms. The mean fold difference between the parent and derivative minimum inhibitory concentration against planktonic cells was 44 forS. epidermidisand 16 forP. aeruginosa. The mean fold difference between the parent and derivative biofilm eradication concentration for 22 tested compounds against bothS. epidermidisandP. aeruginosawas 3. This work demonstrates the possibilities of a new class of biofilm-targeting disinfectants deploying a sulfenate ester functional group to increase the antimicrobial potency toward microorganisms in biofilms.