Different sensitivities to competitive inhibition of benzodiazepine receptor binding of11C-iomazenil and11C-flumazenil in rhesus monkey brain
Different sensitivities to competitive inhibition of benzodiazepine receptor binding of11C-iomazenil and11C-flumazenil in rhesus monkey brain
复制标题
恒河猴脑中11C-碘马西尼和11C-氟马西尼竞争性抑制苯二氮卓受体结合的不同敏感性
DOI：
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发表时间：
2001
影响因子：
2.6
通讯作者：
Kazutoshi Suzuki
中科院分区：
文献类型：
--
作者：
O. Inoue;R. Hosoi;K. Kobayashi;T. Itoh;Antony D. Gee;Kazutoshi Suzuki
Thein vivo binding kineties of11C-iomazenil were compared with those of11C-flumazenll binding in rhesus monkey brain. The monkey was anesthetized with ketamine and intravenously injected with either11C-iomazenil or11C-flumazenil in combination with the coadministration of different doses of non-radioactive flumazenil (0,5 and 20 μg/kg).The regional distribution of11C-iomazenil in the brain was similar to that of11C-flumazenil, but the sensitivity of11C-iomazenil binding to competitive inhibition by non-radioactive flumazenil was much less than that of11C-flumazenil binding. A significant reduction in11C-flumazenil binding in the cerebral cortex was observed with 20 μg/kg of flumazenil, whereas a relatively smaller inhibition of11C-iomazenil binding in the same region was observed with the same dose of flumazenil. These results suggest that11C-flumazenil may be a superior radiotracer for estimating benzodiazepine receptor occupancy in the intact brain.
