Fe/Cr- and Co/Cr-mediated catalytic asymmetric 2-haloallylations of aldehydes
Fe/Cr- and Co/Cr-mediated catalytic asymmetric 2-haloallylations of aldehydes
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DOI：
10.1021/ja045557j
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发表时间：
2004-10-06
影响因子：
15
通讯作者：
Kishi, Y
中科院分区：
文献类型：
--
作者：
Kurosu, M;Lin, MH;Kishi, Y
报道了醛与3-溴-2-卤丙烯催化不对称偶联的第一个例子。偶联反应是通过使用手性磺胺- Cr配合物（由1d， CrBr3, Fe（III）或Co(II)， Et3N和Mn原位制备），TMSCl和2,6-lutidine来实现的。本文报道的方法操作简单，可扩展，提供3-卤代同丙烯醇对映体过量的合成有用水平。
The first example to couple aldehydes and 3-bromo-2-halopropenes in a catalytic asymmetric manner is reported. The coupling reaction is effected by the use of a chiral sulfonamide−Cr complex (prepared in situ from1d, CrBr3, Fe(III) or from Co(II), Et3N, and Mn), TMSCl, and 2,6-lutidine. The method reported here is operationally simple and scalable, furnishing 3-halohomoallylic alcohols with a synthetically useful level of enantiomeric excess.