Comparative Pharmacokinetics Study after Oral Administration of Geniposide in Normal Rats and Adjuvant-induced Arthritis Rats by UPLC-MS/MS
Comparative Pharmacokinetics Study after Oral Administration of Geniposide in Normal Rats and Adjuvant-induced Arthritis Rats by UPLC-MS/MS
复制标题
UPLC-MS/MS 口服京尼平苷在正常大鼠和佐剂性关节炎大鼠体内药代动力学比较研究
DOI：
10.1111/bcpt.12113
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发表时间：
2013-11-01
影响因子：
3.1
通讯作者：
Wu, Huan
中科院分区：
文献类型：
--
作者：
Li, Hui;Wu, Hong;Wu, Huan
建立了一种简便、快速的超高效液相色谱-电喷雾串联质谱（UPLC-ESI-MS/MS）定量分析大鼠血浆中京尼平苷（GE）的方法，并应用于测定口服GE后AA大鼠和正常大鼠血浆中GE的浓度。结果表明，正常大鼠和AA大鼠的药动学参数，如时间-药物浓度曲线下面积（AUC（0-））（3.77 ± 0.68vs2.27 ± 0.42，p
A simple and rapid ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry (UPLC-ESI-MS/MS) method for quantitative analysis of geniposide (GE) in rat plasma was developed, validated and applied to determine the level of GE in rat plasma after oral administration of GE in adjuvant-induced arthritis (AA) and normal rats. The investigation showed that there were significant differences in the groups between the normal rat and AA rat in pharmacokinetics parameters, such as the area under the time versus drug concentration curve (AUC ((0-))) (3.77 +/- 0.68 versus 2.27 +/- 0.42, p