Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection
Antigen persistence and the control of local T cell memory by migrant respiratory dendritic cells after acute virus infection
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DOI：
10.1084/jem.20092017
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发表时间：
2010-06-07
影响因子：
15.3
通讯作者：
Braciale, Thomas J.
中科院分区：
文献类型：
--
作者：
Kim, Taeg S.;Hufford, Matthew M.;Braciale, Thomas J.
急性病毒感染会诱发强大的适应性免疫反应，从而清除病毒。最近的证据表明，病毒清除后，引流淋巴结 (DLN) 中可能存在持续存在的病毒抗原库，因此可能影响适应性免疫反应和记忆 T 细胞的形成。这些残留抗原库的性质、抗原持久性的机制以及持久性抗原对记忆 T 细胞的影响仍然不明确。使用呼吸道流感病毒感染的小鼠模型，我们确定呼吸道树突状细胞（RDC）对于采样和呈递残留病毒抗原至关重要。先前感染的肺部中的 RDC 捕获沉积在抗辐射细胞类型中的残留病毒抗原。然后，RDC 将病毒抗原转运至排泄感染部位的 LN，并在那里将抗原呈递给 T 细胞。最后，我们记录了病毒清除后，由于迁移 RDC 呈递残留病毒抗原，记忆 T 细胞优先定位到 DLN。
Acute viral infections induce robust adaptive immune responses resulting in virus clearance. Recent evidence suggests that there may be depots of viral antigen that persist in draining lymph nodes (DLNs) after virus clearance and could, therefore, affect the adaptive immune response and memory T cell formation. The nature of these residual antigen depots, the mechanism of antigen persistence, and the impact of the persistent antigen on memory T cells remain ill defined. Using a mouse model of influenza virus infection of the respiratory tract, we identified respiratory dendritic cells (RDCs) as essential for both sampling and presenting residual viral antigen. RDCs in the previously infected lung capture residual viral antigen deposited in an irradiation-resistant cell type. RDCs then transport the viral antigen to the LNs draining the site of infection, where they present the antigen to T cells. Lastly, we document preferential localization of memory T cells to the DLNs after virus clearance as a consequence of presentation of residual viral antigen by the migrant RDC.